NCT05791201Active, not recruitingPhase 1/2
A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes
A Phase 1/2 Study to Evaluate the Safety, Tolerability, and Efficacy of VX-264 in Subjects With Type 1 Diabetes Mellitus
Source: ClinicalTrials.gov · Last updated 9 Oct 2026
Brief summary (registry, in English)
The purpose of the study is to evaluate the safety, tolerability, and efficacy of VX-264 in participants with type 1 diabetes (T1D).
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 1/2
- Study type
- Interventional
- Enrollment
- 7 (actual)
- First submitted
- 16 Mar 2023
- Start date
- 16 May 2023
- Primary completion date
- 12 Mar 2027
- Lead sponsor
- Vertex Pharmaceuticals Incorporated
- Diseases
- Type 1 diabetes, Type 2 diabetes
- NCT number
- NCT05791201
- EU CT number
- 2024-515583-32-00
- EudraCT number
- 2022-003318-35
What you commit to
- Study type: Interventional · Phase 1/2
- Participants enrolled: 7
- From 16 May 2023 to the primary completion date, 12 Mar 2027
- 17 sites in 7 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior islet cell transplant, organ transplant, or cell therapy
Who the study is looking for
- Clinical history of T1D with greater than or equal to (\>=) 5 years duration Participant is on a stable diabetic treatment Consistent use of continuous glucose monitoring (CGM) for at least 4 weeks before Screening and willingness to use CGM for the duration of the study
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (17)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Alberta Edmonton Coordinator of this site? Confirm its status | Edmonton | Canada | Unknown status |
| Montreal Clinical Research Institute Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
| Toronto General Hospital (TGH) Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Vancouver General Hospital Coordinator of this site? Confirm its status | Vancouver | Canada | Unknown status |
| Hopiteaux Universitaires de Geneve Coordinator of this site? Confirm its status | Geneva | Switzerland | Unknown status |
| Universitaetsklinikum Carl Gustav Carus Dresden an der Technischen Universitaet Dresden AöR Coordinator of this site? Confirm its status | Dresden | Germany | Active, not recruiting |
| Royal Victoria Infirmary Coordinator of this site? Confirm its status | Newcastle upon Tyne | United Kingdom | Unknown status |
| Churchill Hospital Coordinator of this site? Confirm its status | Oxford | United Kingdom | Unknown status |
| Ospedale San Raffaele S.r.l. Coordinator of this site? Confirm its status | Milan | Italy | Active, not recruiting |
| Istituto Mediterraneo Per I Trapianti E Terapie Ad Alta Specializzazione S.r.l. I.S.M.E.T.T. S.r.l. Coordinator of this site? Confirm its status | Palermo | Italy | Active, not recruiting |
| Leids Universitair Medisch Centrum (LUMC) Coordinator of this site? Confirm its status | Leiden | Netherlands | Active, not recruiting |
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| University of Chicago Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| University of Wisconsin Coordinator of this site? Confirm its status | Madison | United States | Unknown status |
| UHealth Diabetes Research Institute Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Hospital of the University of Pennsylvania Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| University of Pittsburgh Medical Center Montefiore Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.