NCT05807373Completed
Differential Diagnosis Between Parkinson's Disease and Multiple System Atrophy Using Digital Speech Analysis - Part 2
Differential Diagnosis Between Parkinson's Disease and Multiple System Atrophy Using Digital Speech Analysis - Part 2 - Voice4PD-MSA-II
Source: ClinicalTrials.gov · Last updated 24 Jun 2026
Brief summary (registry, in English)
Parkinson's disease (PD) is the second most common neurodegenerative disease. Multiple system atrophy (MSA) is a relentlessly progressing rare neurodegenerative disease of unknown etiology. The differential diagnosis between the MSA-Parkinsonism (MSA-P) subtype and PD can be very challenging in early disease stages, while early diagnostic certitude is important for the patient because of the diverging prognosis. At the time being, there exists no validated objective biomarker to guide the clinician. Dysarthria is a common early symptom in both diseases and of different origin. The ambition and the originality of this project are to develop a digital voice-based tool for objective discrimination between PD and MSA-P.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 28 (actual)
- First submitted
- 24 Mar 2023
- Start date
- 21 Mar 2023
- Primary completion date
- 3 Sept 2024
- Lead sponsor
- University Hospital, Bordeaux
- Diseases
- Parkinson disease
- NCT number
- NCT05807373
What you commit to
- Study type: Interventional
- Participants enrolled: 28
- From 21 Mar 2023 to the primary completion date, 3 Sept 2024
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Criteria the registry did not label
- Inclusion criteria:
- Age from 30 to 80 years old
- Signed informed consent
- Affiliated to social security
- Patient with PD :
- Diagnosis of idiopathic Parkinson's disease (PD) according to criteria (Postuma et al., 2015)
- Patient PD : Hoehn\&Yahr stage between 1 and 2
- Patient with or without mild to moderate speech troubles: MDS-UPDRS III item 1 ≤ 2
- Patients with MSA-P :
- Diagnosis of Multiple Atrophy System (MSA) Parkinsonian form possible or probable according to current consensus criteria (Gilman et al., 2008)
- Patient MSA-P: score of part IV of the UMSARS ≤ 3 points
- Patient with or without mild to moderate speech troubles: UMSARS II item 2 ≤ 2
- Controls :
- Absence of neurologic and oto-rhino-laryngologic disease
- Exclusion criteria :
- Deafs and/or mutes
- Patient with speech disorders which are not related to MSA or PD
- Person under safeguard justice, guardianship
Age in the registry: 30 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU de Bordeaux - Institut des maladies neurodégénératives de Bordeaux Coordinator of this site? Confirm its status | Bordeaux | France | Unknown status |
| Centre Hospitalier Universitaire de Toulouse Coordinator of this site? Confirm its status | Toulouse | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.