NCT05808920Recruiting
The RESCUE Study: Survival and Functional Outcomes Following Salvage Surgery for RESidual or reCurrent sqUamous cEll Carcinoma of the Head and Neck
Source: ClinicalTrials.gov · Last updated 12 Feb 2026
Brief summary (registry, in English)
The RESCUE study is a combined retrospective and prospective multicentre cohort study investigating the survival and functional outcomes in patients undergoing salvage surgery for recurrent, residual, and new primary head and neck squamous cell carcinoma (SCC). Additionally, the RESCUE study will contain an exploratory molecular analysis of consenting patients to assess the relationship between cancer genomics, previous radiotherapy, and recurrence in head and neck cancer.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 400 (estimated)
- First submitted
- 8 Feb 2023
- Start date
- 8 Sept 2023
- Primary completion date
- 30 Apr 2028
- Lead sponsor
- Royal Marsden NHS Foundation Trust
- Diseases
- Head and neck cancer
- NCT number
- NCT05808920
What you commit to
- Study type: Observational
- Planned participants: 400
- From 8 Sept 2023 to the primary completion date, 30 Apr 2028
- 9 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Thyroid, salivary gland, and non-squamous cell H\&N cancers
Other
- Nasopharyngeal and cutaneous SCC of the H\&N
- Presence of distant metastasis (M1) or surgically inoperable T4b tumours
Who the study is looking for
- Aged over 18
- Previous H\&N SCC treated with radiotherapy with or without chemotherapy
- Local or regionally recurrent, residual, or new primary SCC of the oropharynx, oral cavity, larynx, and hypopharynx
- Ability to give informed consent for biological sample collection (molecular analysis study only)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (9)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospitals Derby and Burton Coordinator of this site? Confirm its status | Derby | United Kingdom | Recruiting |
| NHS Lothian Coordinator of this site? Confirm its status | Edinburgh | United Kingdom | Recruiting |
| Western General, Greater Glasgow and Clyde Coordinator of this site? Confirm its status | Glasgow | United Kingdom | Recruiting |
| Aintree Hospital Coordinator of this site? Confirm its status | Liverpool | United Kingdom | Recruiting |
| Head and Neck Unit, Royal Marsden Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Northwick Park Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Oxford University Hospital NHS Foundation Trust Coordinator of this site? Confirm its status | Oxford | United Kingdom | Recruiting |
| Poole Hospital, University Hospitals Dorset Coordinator of this site? Confirm its status | Poole | United Kingdom | Recruiting |
| South Tyneside and Sunderland NHS Foundation Trust Coordinator of this site? Confirm its status | Sunderland | United Kingdom | Completed |
This page is information, not medical advice. Discuss any trial with your doctor.