NCT05809284Recruiting
Determining the Mechanisms of Loss of CAR T Cell Persistence
Source: ClinicalTrials.gov · Last updated 7 Aug 2026
Brief summary (registry, in English)
A prospective observational study of pediatric and young adult acute lymphoblastic leukaemia (ALL) patients treated with CD19 chimeric antigen receptor T-cells (CAR-T cells). The study will examine changes in CAR-T persistence over time and causal factors.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 50 (estimated)
- First submitted
- 3 Mar 2023
- Start date
- 18 Oct 2023
- Primary completion date
- 1 Jul 2027
- Lead sponsor
- University College, London
- NCT number
- NCT05809284
What you commit to
- Study type: Observational
- Planned participants: 50
- From 18 Oct 2023 to the primary completion date, 1 Jul 2027
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients receiving an alternate CD19-directed CAR T-cell product on a clinical trial
Other
- Any reason that in the opinion of the investigator, patients won't be able to adhere to the protocol
Who the study is looking for
- Children and young adults (age 25 years or younger) with relapsed/refractory ALL who are planned to receive licensed CD19-targeted CAR-T cell treatment (Tisagenlecleucel)
- Written informed consent
Age in the registry: - to 25 years · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University College London Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Great Ormond Street Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Royal Manchester Children's Hospital Coordinator of this site? Confirm its status | Manchester | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.