NCT05818475Active, not recruiting
Functional Coronary Angiography Guided Revascularization in STEMI
Functional Coronary Angiography to Indicate and Guide Revascularization in STEMI Patients With Multivessel Disease
Source: ClinicalTrials.gov · Last updated 1 May 2026
Brief summary (registry, in English)
The goal of this multicenter randomized clinical trial is to test the superiority in terms of efficacy of the Angiography-derived fractional flow reserve (AIR) over that based on conventional angiography (ANGIO) strategy in the management of non-culprit lesions in STEMI patients with multivessel disease. The main questions it aims to answer are: * is an Angiography-derived fractional flow reserve strategy superior to a conventional angiography strategy in reducing the occurrence of the composite efficacy endpoint of all-cause death, myocardial infarction, cerebrovascular accident, or ischemia-driven revascularization. * is an Angiography-derived fractional flow reserve strategy superior to a conventional angiography strategy in reducing the occurrence of the composite safety endpoint of of contrast-associated acute kidney injury and Bleeding Academic Research Consortium (BARC) type 3-5. Participants will be randomized after the successful treatment of the culprit lesion to one of the two strategies and prospectively followed-up.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 1823 (actual)
- First submitted
- 22 Mar 2023
- Start date
- 8 May 2023
- Primary completion date
- 31 Jan 2026
- Lead sponsor
- University Hospital of Ferrara
- Diseases
- Coronary artery disease
- NCT number
- NCT05818475
What you commit to
- Study type: Interventional
- Participants enrolled: 1823
- From 8 May 2023 to the primary completion date, 31 Jan 2026
- 22 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Planned surgical revascularization
- Prior Coronary Artery Bypass Graft (CABG) Surgery
Other
- Left main as non-culprit lesion
- Non-cardiovascular co-morbidity reducing life expectancy to \< 1 year
- Any factor precluding 1-year follow-up
- Impossibility to identify a clear culprit lesion
- Presence of a chronic total occlusion (CTO)
Who the study is looking for
- ST-segment elevation myocardial infarction with indication to invasive management
- Multi-vessel disease defined as at least 1 non-culprit coronary artery lesion at least 2.5 mm in diameter deemed at visual estimation with a diameter stenosis % ranging from 50 to 99% amenable to successful treatment with PCI
- Successful treatment of culprit lesion
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (22)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ospedale Civile di Baggiovara Coordinator of this site? Confirm its status | Baggiovara | Italy | Unknown status |
| Asst Papa Giovanni XXIII Coordinator of this site? Confirm its status | Bergamo | Italy | Unknown status |
| AUSL Bologna Ospedale Maggiore Coordinator of this site? Confirm its status | Bologna | Italy | Unknown status |
| Ospedale di Bolzano Coordinator of this site? Confirm its status | Bolzano | Italy | Unknown status |
| AORN Sant'Anna e San Sebastiano Coordinator of this site? Confirm its status | Caserta | Italy | Unknown status |
| Azienda Ospedaliero-Universitaria Mater Domini Coordinator of this site? Confirm its status | Catanzaro | Italy | Unknown status |
| Ospedale Annunziata Coordinator of this site? Confirm its status | Cosenza | Italy | Unknown status |
| Azienda Ospedaliero Universitaria di Ferrara Coordinator of this site? Confirm its status | Ferrara | Italy | Unknown status |
| Ospedale Santa Maria Goretti Coordinator of this site? Confirm its status | Latina | Italy | Unknown status |
| Ospedale Mater Salutis Legnago Coordinator of this site? Confirm its status | Legnago | Italy | Unknown status |
| Ospedale dell'Angelo - Mestre Coordinator of this site? Confirm its status | Mestre | Italy | Unknown status |
| Ospedale Maggiore della carità - Novara Coordinator of this site? Confirm its status | Novara | Italy | Unknown status |
| Azienda Ospedaliero Universitaria di Parma Coordinator of this site? Confirm its status | Parma | Italy | Unknown status |
| AUSL Piacenza Coordinator of this site? Confirm its status | Piacenza | Italy | Unknown status |
| Azienda Ospedaliero Universitaria Pisana Coordinator of this site? Confirm its status | Pisa | Italy | Unknown status |
| AUSL Romagna Santa Maria delle Croci Ravenna Coordinator of this site? Confirm its status | Ravenna | Italy | Unknown status |
| Arcispedale Santa Maria Nuova di Reggio Emilia Coordinator of this site? Confirm its status | Reggio Emilia | Italy | Unknown status |
| AUSL Romagna Ospedale degli Infermi Rimini Coordinator of this site? Confirm its status | Rimini | Italy | Unknown status |
| Policlinico Casilino Coordinator of this site? Confirm its status | Roma | Italy | Unknown status |
| Ospedale Santa Maria della Misericordia Rovigo Coordinator of this site? Confirm its status | Rovigo | Italy | Unknown status |
| Azienda Ospedaliero Universitaria Integrata di Verona Coordinator of this site? Confirm its status | Verona | Italy | Unknown status |
| NICVD Karachi Coordinator of this site? Confirm its status | Karachi | Pakistan | Unknown status |
Related publications
- Complete Revascularization Guided by Functional Coronary Angiography in STEMI.N Engl J Med · 2026 · PMID 42670979
- Management of multivessel disease in patients with ST-segment elevation myocardial infarction: questioning routine immediate complete revascularization in all patients.Coron Artery Dis · 2026 · PMID 42423587
This page is information, not medical advice. Discuss any trial with your doctor.