NCT05822388Recruiting
Cognitive Decline Following Deep Brain Stimulation
A Neural Basis for Cognitive Decline Following Deep Brain Stimulation
Source: ClinicalTrials.gov · Last updated 29 May 2026
Brief summary (registry, in English)
This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS). In particular, this study will focus on changes in cognition associated with DBS. A total of 55 participants with Parkinson's Disease planning to undergo DBS will be recruited from MUSCs Clinical DBS Program. Participants will undergo four visits, including a 1-hour screening visit, a 1.5-hour pre-DBS MRI scanning visit, and a 3.5-hour post-DBS cognitive assessment visit. In addition control participants without Parkinson's Disease will be recruited to undergo MRI scanning and cognitive assessments.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 80 (estimated)
- First submitted
- 10 Apr 2023
- Start date
- 1 Apr 2023
- Primary completion date
- 31 Mar 2027
- Lead sponsor
- Medical University of South Carolina
- Diseases
- Parkinson disease
- NCT number
- NCT05822388
What you commit to
- Study type: Observational
- Planned participants: 80
- From 1 Apr 2023 to the primary completion date, 31 Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Non-MRI compatible metal implants (surgical clips or staples, cardiac pacemakers etc.)
- Non-PD Control Participants
- Diagnosis of Parkinsons Disease or other movement disorder
- Untreated neuropsychiatric disorders
- Non-MRI compatible metal implants (surgical clips or staples, cardiac pacemakers etc.)
Other
- Uncorrected visual or hearing impairments, as indicated by self-report
- Individuals who are pregnant or expect to become pregnant during the course of the study
- Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner
- COPD with oxygen dependence
- Uncorrected visual or hearing impairments, as indicated by self-report
- Individuals who are pregnant or expect to become pregnant during the course of the study
- Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner
- COPD with oxygen dependence
Who the study is looking for
- Subjects above 18 years of age
- Subjects who will undergo DBS surgery as part of their clinical care for PD
- Subjects above 18 years of age
- Age matched to participants in PD group
Criteria the registry did not label
- PD Participants
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical University of South Carolina Coordinator of this site? Confirm its status | Charleston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.