NCT05824520Recruiting
Coronary CT-Derived FFR-Guided Strategy Versus Medical Therapy
Coronary Computed Tomography-Derived Fraction Flow Reserve (FFR)-Guided Invasive Treatment Strategy (ITS) Versus Optimal Medical Therapy (OMT) Alone in Patient With Chronic Coronary Syndrome
Source: ClinicalTrials.gov · Last updated 2 Feb 2026
Brief summary (registry, in English)
The overall purpose of ACCURATE II trial is to compare the clinical outcomes of CT-derived FFR guided strategy versus medical therapy in patients with chronic coronary syndrome.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 1066 (estimated)
- First submitted
- 6 Mar 2023
- Start date
- 10 Oct 2024
- Primary completion date
- 20 Oct 2028
- Lead sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
- Diseases
- Coronary artery disease
- NCT number
- NCT05824520
What you commit to
- Study type: Interventional
- Planned participants: 1066
- From 10 Oct 2024 to the primary completion date, 20 Oct 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG)
Other illness
- The patient has a known hypersensitivity or contraindication to any of the following medications: Heparin, Aspirin, Clopidogrel, Prasugrel, Ticagrelor, Contrast media (Patients with documented sensitivity to contrast media which can be effectively pre-medicated with steroids and diphenhydramine \[e.g. rash\] may be enrolled)
- Sinus arrhythmia, cardiogenic shock, or severe heart failure (NYHA≥III)
- Patients on hemodialysis or with severe hepatic or renal insufficiency
Other
- Inability or unwillingness to undergo CT scan or coronary angiography
- Left main coronary artery stenosis ≥ 50%
- Target vessel total occlusion
- Pregnancy or intention to become pregnant during the course of the trial
- Patients with a life expectancy less than 2 years
Who the study is looking for
- Age ≥ 18 years, with at least one vessel has CT-derived FFR≤0.80
- Patients with chronic coronary syndromes
- Signed written informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Second Affiliated Hospital, School of Medicine, Zhejiang University Coordinator of this site? Confirm its status | Hangzhou | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.