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NCT05827237Completed

Rule Out of ACS in Primary Care Using a Decision Rule for Chest Pain Including Hs-troponin I POCT

Primary Care Decision Rule for Chest Pain Using the Marburg Heart Score and Hs-troponin I Point of Care Test to Rule Out Acute Coronary Syndrome

Source: ClinicalTrials.gov · Last updated 10 Sept 2025

Brief summary (registry, in English)

The goal of this clustered, diagnostic randomized controlled trial is to study a clinical decision rule including a high-sensitive troponin I point of care test in patients with chest pain in primary care. The main questions it aims to answer are: 1. Can unnecessary referrals to secondary care be reduced by the use of a clinical deci-sion rule in patients with new onset, non-traumatic chest pain in primary care? Compared to current daily practice. 2. What is the accuracy (sensitivity, negative prediction value) of the clinical decision rule for excluding ACS and MACE at 6 weeks and 6 months?

Status (registry)
Completed
Study type
Interventional
Enrollment
946 (actual)
First submitted
21 Mar 2023
Start date
18 Aug 2021
Primary completion date
5 Feb 2025
Lead sponsor
Leiden University Medical Center
NCT number
NCT05827237

What you commit to

  • Study type: Interventional
  • Participants enrolled: 946
  • From 18 Aug 2021 to the primary completion date, 5 Feb 2025
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other

  • \<1 hour since onset of symptoms
  • Inability to speak or understand Dutch
  • Hemodynamic instability

Who the study is looking for

  • ≥18 years of age
  • Acute chest pain
  • Seen by general practitioner

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Leiden University Medical Center
Coordinator of this site? Confirm its status
LeidenNetherlandsUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.