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NCT05827887Completed

An Observational Study to Assess Ubrogepant Tablets and Atogepant Tablets to Treat Migraine in Adult Participants

ProspeCtive Observational Real-world Study of uBRogepant and Atogepant in Israel (COBRA)

Source: ClinicalTrials.gov · Last updated 3 Apr 2026

Brief summary (registry, in English)

Migraine is a neurological disease characterized by moderate or severe headache, associated with nausea, vomiting, and/or sensitivity to light and sound. This study will evaluate how effective the use of ubrogepant and atogepant is in treating adult participants with migraine. Urogepant (Ubrelvy) and Atogepant (Qulipta) are approved drugs for treatment of migraine in adults in the US. Approximately 200 adult participants who are prescribed Ubrogepant or atogepant by their doctors will be enrolled in this study in Israel. Participants will receive ubrogepant oral tablets or atogepant oral tablets as prescribed by their physician. Participants will be followed for 90 days. There is expected to be no additional burden for participants in this trial. Participants will attend regular visits during the study at a hospital or clinic according to their routine clinical practice.

Status (registry)
Completed
Study type
Observational
Enrollment
226 (actual)
First submitted
13 Apr 2023
Start date
25 Jun 2023
Primary completion date
28 Jan 2026
Lead sponsor
AbbVie
Diseases
Migraine
NCT number
NCT05827887

What you commit to

  • Study type: Observational
  • Participants enrolled: 226
  • From 25 Jun 2023 to the primary completion date, 28 Jan 2026
  • 11 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study design.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Patients who cannot be treated with UBRO or ATO according to the applicable approved label
  • Patients participating in a concurrent clinical interventional study or within the last 30 days
  • Patients who were previously treated with rimegepant will be excluded from the study

Who the study is looking for

  • Confirmed diagnosis of migraine according to the ICHD-3 upon judgement of the treating physician
  • The patients should be naive to the designated treatment
  • Ability to fill an e-diary app

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (11)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
Assuta Ashdod Medical Center /ID# 260020
Coordinator of this site? Confirm its status
AshdodIsraelUnknown status
Soroka University Medical Center /ID# 254551
Coordinator of this site? Confirm its status
BeershebaIsraelUnknown status
Clalit HMO /ID# 257364
Coordinator of this site? Confirm its status
Gani TikvaIsraelUnknown status
Edith Wolfson Medical Center /ID# 269740
Coordinator of this site? Confirm its status
HolonIsraelUnknown status
Hadassah Medical Center-Hebrew University /ID# 257352
Coordinator of this site? Confirm its status
JerusalemIsraelUnknown status
Shaare Zedek Medical Center /ID# 254169
Coordinator of this site? Confirm its status
JerusalemIsraelUnknown status
Maccabi Healthcare Services /ID# 254171
Coordinator of this site? Confirm its status
Kfar SabaIsraelUnknown status
Meir Medical Center /ID# 254170
Coordinator of this site? Confirm its status
Kfar SabaIsraelUnknown status
The Chaim Sheba Medical Center /ID# 254550
Coordinator of this site? Confirm its status
Ramat GanIsraelUnknown status
ZIV Medical Center /ID# 257360
Coordinator of this site? Confirm its status
SafedIsraelUnknown status
Tel Aviv Sourasky Medical Center /ID# 263089
Coordinator of this site? Confirm its status
Tel AvivIsraelUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.