NCT05827887Completed
An Observational Study to Assess Ubrogepant Tablets and Atogepant Tablets to Treat Migraine in Adult Participants
ProspeCtive Observational Real-world Study of uBRogepant and Atogepant in Israel (COBRA)
Source: ClinicalTrials.gov · Last updated 3 Apr 2026
Brief summary (registry, in English)
Migraine is a neurological disease characterized by moderate or severe headache, associated with nausea, vomiting, and/or sensitivity to light and sound. This study will evaluate how effective the use of ubrogepant and atogepant is in treating adult participants with migraine. Urogepant (Ubrelvy) and Atogepant (Qulipta) are approved drugs for treatment of migraine in adults in the US. Approximately 200 adult participants who are prescribed Ubrogepant or atogepant by their doctors will be enrolled in this study in Israel. Participants will receive ubrogepant oral tablets or atogepant oral tablets as prescribed by their physician. Participants will be followed for 90 days. There is expected to be no additional burden for participants in this trial. Participants will attend regular visits during the study at a hospital or clinic according to their routine clinical practice.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 226 (actual)
- First submitted
- 13 Apr 2023
- Start date
- 25 Jun 2023
- Primary completion date
- 28 Jan 2026
- Lead sponsor
- AbbVie
- Diseases
- Migraine
- NCT number
- NCT05827887
What you commit to
- Study type: Observational
- Participants enrolled: 226
- From 25 Jun 2023 to the primary completion date, 28 Jan 2026
- 11 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who cannot be treated with UBRO or ATO according to the applicable approved label
- Patients participating in a concurrent clinical interventional study or within the last 30 days
- Patients who were previously treated with rimegepant will be excluded from the study
Who the study is looking for
- Confirmed diagnosis of migraine according to the ICHD-3 upon judgement of the treating physician
- The patients should be naive to the designated treatment
- Ability to fill an e-diary app
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (11)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Assuta Ashdod Medical Center /ID# 260020 Coordinator of this site? Confirm its status | Ashdod | Israel | Unknown status |
| Soroka University Medical Center /ID# 254551 Coordinator of this site? Confirm its status | Beersheba | Israel | Unknown status |
| Clalit HMO /ID# 257364 Coordinator of this site? Confirm its status | Gani Tikva | Israel | Unknown status |
| Edith Wolfson Medical Center /ID# 269740 Coordinator of this site? Confirm its status | Holon | Israel | Unknown status |
| Hadassah Medical Center-Hebrew University /ID# 257352 Coordinator of this site? Confirm its status | Jerusalem | Israel | Unknown status |
| Shaare Zedek Medical Center /ID# 254169 Coordinator of this site? Confirm its status | Jerusalem | Israel | Unknown status |
| Maccabi Healthcare Services /ID# 254171 Coordinator of this site? Confirm its status | Kfar Saba | Israel | Unknown status |
| Meir Medical Center /ID# 254170 Coordinator of this site? Confirm its status | Kfar Saba | Israel | Unknown status |
| The Chaim Sheba Medical Center /ID# 254550 Coordinator of this site? Confirm its status | Ramat Gan | Israel | Unknown status |
| ZIV Medical Center /ID# 257360 Coordinator of this site? Confirm its status | Safed | Israel | Unknown status |
| Tel Aviv Sourasky Medical Center /ID# 263089 Coordinator of this site? Confirm its status | Tel Aviv | Israel | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.