NCT05829317RecruitingPhase 4
Magnesium Prophylaxis for the Prevention of New-Onset Atrial Fibrillation in Critically Ill Patients
Parenteral Magnesium Prophylaxis for the Prevention of New-Onset Atrial Fibrillation in Critically Ill Patients - a Pilot Feasibility Study
Source: ClinicalTrials.gov · Last updated 22 Sept 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
A double-blind, multi-centre, randomized, placebo-controlled, feasibility pilot trial in the prevention of new onset atrial fibrillation of critically ill patients admitted to an ICU.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 200 (estimated)
- First submitted
- 15 Mar 2023
- Start date
- 20 Aug 2023
- Primary completion date
- 1 Mar 2028
- Lead sponsor
- Dr. Stephanie Sibley
- Diseases
- Atrial fibrillation
- NCT number
- NCT05829317
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 200
- From 20 Aug 2023 to the primary completion date, 1 Mar 2028
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Receiving ICU intervention (Non-invasive ventilation (including high flow nasal canula), invasive mechanical ventilation or inotropic support) for \>18 hours
- Receiving IMV for airway protection only (for example, isolated head trauma)
- Patients receiving dialysis
- Previously enrolled in this trial
Other illness
- Cardiac surgery patients
Lab values
- Patients requiring parenteral magnesium therapy (e.g. pre-eclampsia, asthma)
Age
- Positive pregnancy test (females \<50 years old)
Other
- Active atrial fibrillation at the time of enrolment
- On oral or continuous infusion of Amiodarone
- Unlikely to survive \>24 hours or palliative patients
- Treating physician refuses enrollment
Who the study is looking for
- Age ≥18 years;
- Admitted to an ICU with one or more of the following:
- Non-invasive ventilation (including CPAP, Bipap and high flow oxygen (\>10L/min) or invasive mechanical ventilation with an expected duration \>24 hours for respiratory failure (hypercarbic or hypoxic)
- Vasopressor or inotropic support with an expected duration of \>24 hours
- Cardiac arrest
- Continuous cardiac monitoring.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| St. Joseph's Healthcare Hamilton Coordinator of this site? Confirm its status | Hamilton | Canada | Not yet recruiting |
| Kingston Health Sciences Centre Coordinator of this site? Confirm its status | Kingston | Canada | Recruiting |
| The Ottawa Hospital - General Campus Coordinator of this site? Confirm its status | Ottawa | Canada | Not yet recruiting |
| The Ottawa Hospital - Civic Campus Coordinator of this site? Confirm its status | Ottawa | Canada | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.