NCT05832567Recruiting
Mechanisms of Open and Hidden Placebo in Stroke Recovery
Source: ClinicalTrials.gov · Last updated 14 Jul 2026
Brief summary (registry, in English)
This trial aims to investigate whether placebo in isolation (open and hidden) has a specific neural signature in stroke subjects thus providing a novel mechanism to explain placebo effects that can be used to ultimately enhance stroke rehabilitation therapies.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 56 (estimated)
- First submitted
- 24 Mar 2023
- Start date
- 11 Sept 2023
- Primary completion date
- 1 Jun 2026
- Lead sponsor
- Spaulding Rehabilitation Hospital
- Diseases
- Stroke
- NCT number
- NCT05832567
What you commit to
- Study type: Interventional
- Planned participants: 56
- From 11 Sept 2023 to the primary completion date, 1 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- TMS contraindications: electronic hardware in close contact to the discharging coil such as cochlear implant, internal pulse generator or medical pump
- Concurrent unstable medical conditions
Other illness
- Stroke of anterior cerebral artery territory with prefrontal lesion and stroke-related decreased EEG power in the prefrontal cortex
Other
- Unable to understand instructions
- A score of 24 or higher on the Hamilton Depression Rating Scale (HDRS)
- Joint or paretic extremity pain likely to interfere with assessments
- Pregnancy
Who the study is looking for
- Adults with hemiparesis due to chronic stroke
- Stroke duration of 6 months or more
- Fugl-Meyer scale upper extremity motor assessment score of \> 11 and ≤ 56
- Pre-stroke disability (defined as a score of \< 3 on the Modified Rankin Scale)
- Age 18 or older
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Spaulding Hospital Cambridge Coordinator of this site? Confirm its status | Cambridge | United States | Recruiting |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.