NCT05833217Recruiting
Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2
Obesity, Insulin Resistance, and PASC: Persistent SARS-CoV-2 Infection and Inflammation in Human Adipose Tissue
Source: ClinicalTrials.gov · Last updated 4 Dec 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The investigators are studying the pathophysiologic links between obesity, insulin resistance (IR), adipose tissue infection, and post-acute sequelae of COVID-19 (PASC). This study looks at whether adipose (fat) tissue contributes to PASC by driving chronic inflammation or by serving as a reservoir for SARS-CoV-2 persistence. The results will not only determine whether obesity and IR are risk factors for PASC, but will also define fundamental biology that sets the stage for the investigation of novel or existing therapies that target the causal pathways identified.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 55 (estimated)
- First submitted
- 26 Apr 2023
- Start date
- 6 Jun 2023
- Primary completion date
- 2 May 2025
- Lead sponsor
- Stanford University
- Diseases
- Obesity, Long COVID and ME/CFS
- NCT number
- NCT05833217
What you commit to
- Study type: Interventional
- Planned participants: 55
- From 6 Jun 2023 to the primary completion date, 2 May 2025
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- prior liposuction
- bariatric surgery
- use of weight loss medication or oral steroids
Other illness
- bleeding disorders
- major organ disease
- diabetes
- history of liposuction
- eating disorders
- psychiatric disorders
Lab values
- fasting glucose \>= 126 mg/dL
Other
- Arm 2 (Adipose Tissue Biopsy) exclusions include
- pregnancy
- recent change in weight (\> 2 kg in one month)
- anticoagulant use
- Arm 3 (healthy controls only) exclusions include patients with
- pregnancy or lactation
- recent change in weight (over the past 12 weeks),
- hematocrit \< 33%
- blood pressure \>160/100 mmHg
Who the study is looking for
- Ages 18 to 80
- BMI ≥ 25 kg/m2
- not currently pregnant
Age in the registry: 18 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Stanford Health Coordinator of this site? Confirm its status | Palo Alto | United States | Recruiting |
| Clinical and Translational Research Unit Coordinator of this site? Confirm its status | Palo Alto | United States | Enrolling by invitation |
This page is information, not medical advice. Discuss any trial with your doctor.