NCT05833542Completed
Assessing Perceptions and Preferences Around Long-acting Injectables (APPLI)
Assessing Perceptions and Preferences Around Long-acting Injectables in the Ryan White HIV/AIDS Program
Source: ClinicalTrials.gov · Last updated 21 Mar 2025
Brief summary (registry, in English)
The Ryan White HIV/AIDS Program is an essential platform for reducing health disparities among people with HIV and scaling up evidence-based strategies to strengthen the HIV care continuum. The investigators propose an implementation-science study based in New York Ryan White Part A programs, to inform the delivery of long-acting injectable antiretroviral therapy and related supportive services to low-income, largely Black and Latino/a people with HIV who have struggled with daily oral antiretroviral therapy adherence. As a major biomedical advance de-necessitating adherence to daily dosing, long-acting injectable antiretroviral therapy could greatly increase opportunities for health, survival and transmission prevention, particularly in populations confronting complex barriers to viral load suppression. However, optimizing the public health impact of long-acting injectable antiretroviral therapy will require implementation science to assess perceptions and preferences around long-acting injectable versus daily oral regimens, identify support services and delivery mechanisms suited to promoting long-acting injectable uptake and engagement, and address the role of provider beliefs as to which patients should be offered long-acting injectable options. In the absence of this groundwork, long-acting injectable antiretroviral therapy may primarily reach those who are already relatively advantaged, and even exacerbate HIV disparities.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 243 (actual)
- First submitted
- 30 Dec 2022
- Start date
- 3 May 2023
- Primary completion date
- 2 Feb 2024
- Lead sponsor
- City University of New York
- Diseases
- HIV
- NCT number
- NCT05833542
What you commit to
- Study type: Interventional
- Participants enrolled: 243
- From 3 May 2023 to the primary completion date, 2 Feb 2024
- 6 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Age
- N/A, aside from age minimum and language requirements already noted above
Who the study is looking for
- Patients: Adults enrolled in Ryan White Part A medical case management services and able to understand materials provided or discussed in English or Spanish. Although minors may possibly receive enhanced services related to the pilot, their data will not be included in pilot analyses. Baseline data from the sites suggest that only 1-2 minors might be served at all in the partnering medical case management programs during the pilot period. Some patients may be able to utilize the decision aid and informational materials in a language other than their primary language, but it is expected that the providers will focus on pilot testing with clients whose primary language is used in the videos and written materials.
- Providers: Adults overseeing or delivering Ryan White Part A medical case management services or prescribing antiretroviral therapy for patients in Ryan White Part A medical case management programs (and able to read and speak English, in that provider data collection will only be conducted in English). It is expected that the 12 providers participating in Aim 3 implementation-focused surveys and interviews about the pilot will already have participated in APPLI in some form during Aim 1 focus groups or Aim 2 discreet choice experiment surveys, and thus will not add to the total number of study enrollees.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (6)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| State University of New York Downstate Health Sciences University Coordinator of this site? Confirm its status | Brooklyn | United States | Unknown status |
| Together Our Unity Can Heal Coordinator of this site? Confirm its status | Congers | United States | Unknown status |
| Open Door Family Medical Centers Coordinator of this site? Confirm its status | Mamaroneck | United States | Unknown status |
| Council on Adoptable Children Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| La Casa De Salud Coordinator of this site? Confirm its status | The Bronx | United States | Unknown status |
| Sun River Health Coordinator of this site? Confirm its status | Yonkers | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.