NCT05842161Recruiting
South Africa Smoking Cessation and Engagement in HIV/TB Care Care
Treatment Development for Smoking Cessation and Engagement in HIV/TB
Source: ClinicalTrials.gov · Last updated 9 Sept 2026
Brief summary (registry, in English)
The purpose of this study is to integrate elements from existing interventions developed by our team into a single intervention (QUIT-AD), designed to improve smoking cessation and favorable HIV/TB treatment outcomes among individuals with HIV and/or TB in Cape Town, South Africa. If feasibility, acceptability, and preliminary efficacy are demonstrated, the intervention will be ready for large-scale effectiveness/implementation testing. This program will has the potential to dramatically improve public health by increasing the smoking quit rate and facilitating favorable HIV/TB treatment outcomes among patients with HIV and/or TB in resource limited South African settings.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 83 (estimated)
- First submitted
- 12 Apr 2023
- Start date
- 12 Mar 2024
- Primary completion date
- 1 May 2027
- Lead sponsor
- Massachusetts General Hospital
- Diseases
- Tuberculosis, HIV
- NCT number
- NCT05842161
What you commit to
- Study type: Interventional
- Planned participants: 83
- From 12 Mar 2024 to the primary completion date, 1 May 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Cognitive Behavioral Therapy for smoking cessation initiated within the past year,
- Diagnosed with extra-pulmonary or drug resistant (MDR or XDR) TB based upon chart review
Other illness
- Current interfering untreated/unstable mental health condition (e.g., psychosis, bipolar dx)
Other
- Current use of non-study pharmacotherapy for smoking cessation,
Who the study is looking for
- Aged 18 or older
- Willing and able to provide written informed consent
- Living with HIV, confirmed via medical record, and history of taking ART for at least three months (consecutively or non-consecutively)
- Within 4 months of initiating or reinitiating TB treatment; positive GeneXpert test or sputum culture
- Habitual smoker operationalized as smoking at least 4 days a week
- Motivation (\> 5/10) to quit smoking or \> 24 hour quit past yr
- Must be living in the catchment area for either the Town Two Clinic or the Michael Mapongwana Community Health Clinic in Khayelitsha
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Cape Town Coordinator of this site? Confirm its status | Rondebosch | South Africa | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.