NCT05842850Recruiting
Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals
Increased Risk of Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals - Reversibility and Mechanistic Studies.
Source: ClinicalTrials.gov · Last updated 4 May 2026
Brief summary (registry, in English)
The investigators will conduct a proof-of-principle 4-weeks low-calorie diet (LCD) intervention study in low birth weight (LBW) subjects and normal birth weight (NBW) controls with documented (MR scan) liver fat content equal to or above 5%. The investigators will provide extended in-depth mechanistic insight into the role of impaired subcutaneous adipose tissue (SAT) expandability in ectopic fat deposition before and after LCD.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 8 (estimated)
- First submitted
- 11 Apr 2023
- Start date
- 1 Jan 2026
- Primary completion date
- Dec 2026
- Lead sponsor
- Steno Diabetes Center Copenhagen
- Diseases
- Fatty liver disease (MASLD/MASH)
- NCT number
- NCT05842850
What you commit to
- Study type: Interventional
- Planned participants: 8
- From 1 Jan 2026 to the primary completion date, Dec 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Family history of diabetes (siblings, parent, and grandparents)
- Disease/medication known to affect primary outcome
- Metabolic/liver disease
Other
- BMI\<18.5 and BMI\>30 kg/m2
- Self-reported high physical activity level
- Alcohol intake above general recommendations.
- Weight gain/loss of \>3 kg within the past 6 months
Who the study is looking for
- subjects with NAFLD (liver fat content ≥5% liver fat content verified on MRS in the screening NAFLD study)
Age in the registry: 35 years to 40 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| steno diabetes center Aarhus Coordinator of this site? Confirm its status | Aarhus | Denmark | Recruiting |
| Steno Diabetes Center Copenhagen Coordinator of this site? Confirm its status | Herlev | Denmark | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.