Effects of Repetitive Transcranial Magnetic Stimulation on Cerebral Autoregulation in Patients With Acute Ischemic Stroke

Prior treatment

• Previous history of epilepsy, family history of epilepsy or presence of seizure provoking factors;
• Those who are participating in other clinical investigators, or who have participated in other clinical studies within 3 months prior to enrollment, or who have participated in this study;

Other illness

• Presence of a medical condition such as severe cognitive impairment or mental impairment;
• Patients with serious physical diseases or who have had craniocerebral surgery;
• The presence of metal foreign bodies near the stimulation site, such as intracranial metal implants, cochlear implants, built-in pulse generators (brain pacemakers, cardiac pacemakers), etc.;
• Other conditions that the investigators deemed unsuitable for enrollment.

Other

• Pregnancy or breastfeeding;
• Patients who are unable to complete cerebral autoregulation, or bilateral temporal window penetration poorly;
• life expectancy of ≤3 months or inability to complete the study for other reasons;
• unwillingness to be followed up or poor treatment compliance;

• Age ≥ 18 years, both sexes;
• Clinically definite diagnosis of acute ischemic stroke;
• Baseline National Institute of Health Stroke Scale (NIHSS) score ≤25;
• Pre-onset modified Rankin Scale (mRS) score ≤1;
• Randomized and initiated transcranial magnetic stimulation within 1 week of onset;
• Subject or legal representative agreed to the treatment and signed the informed consent.