NCT05844514Recruiting
COlorectal BReath Analysis (COBRA2)
The COlorectal BReath Analysis (COBRA2) Study: Non-invasive Breath Testing to Detect Colorectal Cancer
Source: ClinicalTrials.gov · Last updated 13 Jun 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Colorectal cancer (CRC) is the second most common cause of cancer death in the United Kingdom, with approximately 17,000 deaths per year. The five-year survival rate from CRC is only 10% when discovered at a late stage, but exceeds 90% if diagnosed early. Symptoms related to CRC can be non-specific, therefore the decision to refer for a colonoscopy can be challenging. There is a clear need to improve earlier detection of CRC so that patients with CRC can be identified earlier and faster, enabling them to start treatment more quickly. The study team is developing a non-invasive breath test that detects small molecules called volatile organic compounds (VOCs) that are specific to CRC. For patients with non-specific symptoms, this test would help GPs to identify those patients that may have underlying CRC, who would benefit from referral for specialised CRC tests.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 720 (estimated)
- First submitted
- 25 Apr 2023
- Start date
- 23 Sept 2022
- Primary completion date
- 1 Apr 2026
- Lead sponsor
- Imperial College London
- Diseases
- Colorectal cancer
- NCT number
- NCT05844514
What you commit to
- Study type: Observational
- Planned participants: 720
- From 23 Sept 2022 to the primary completion date, 1 Apr 2026
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous surgery altering the anatomy of the lower GI tract (e.g., hemicolectomy, anterior resection).
- Previous treatment (neoadjuvant chemotherapy or radiotherapy or immunotherapy) for CRC.
- Received bowel preparation for their colonoscopy procedure.
Other illness
- History of any other cancer within three years.
Other
- Unable or unwilling to provide informed written consent.
Who the study is looking for
- Patients aged ≥ 18 years referred from primary care with symptoms of suspected CRC.
- Patients with histologically confirmed colorectal adenocarcinoma (stages I-IV) who are treatment naïve (CRC group).
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| St Mark's Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Active, not recruiting |
| West Middlesex University Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Chelsea And Westminster Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Royal Marsden Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Active, not recruiting |
| St Mary's Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.