NCT05846126Completed
Digital Multimodal Rehabilitation for People With Post-acute COVID-19 Syndrome.
Digital Rehabilitation With Cognitive Training, Physical Activity and Mindfulness for People With Post-acute COVID-19 Syndrome With Cognitive Impairment. REHABCOVID Project.
Source: ClinicalTrials.gov · Last updated 30 Apr 2026
Brief summary (registry, in English)
Although most infected people survive the infection, many have persistent sequelae or symptoms, which cause disability or decreased quality of life. The World Health Organization has called on countries to prioritize the rehabilitation of the consequences of COVID-19 in both the medium and long term, as this chronicity is expected to impact the health public and the economy in the coming years. RehabCOVID (also referred to as RehabNautilus) is born from the need to provide solutions to persistent cognitive impairment symptoms of people who have suffered from COVID-19. Thus, we will offer people with long COVID that accomplish inclusion/exclusion criteria to participate in a randomized clinical trial to evaluate the effectiveness of cognitive stimulation therapy combined with physical exercise and mindfulness. The current project is a single-blind randomized control study, where we will compare two combined interventions with a control group that will encompass different functional, structural, and biochemical changes and interactions in the brain. We will study the effects that this combined intervention produces in the brain. We expect to gain more insight into the specific neuroplasticity mechanisms of cognitive persistent COVID symptoms.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 172 (actual)
- First submitted
- 4 May 2023
- Start date
- 5 May 2023
- Primary completion date
- 20 Dec 2024
- Lead sponsor
- Consorci Sanitari de Terrassa
- Diseases
- Long COVID and ME/CFS
- NCT number
- NCT05846126
What you commit to
- Study type: Interventional
- Participants enrolled: 172
- From 5 May 2023 to the primary completion date, 20 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Established diagnosis before COVID-19 disease of psychiatric, neurological, developmental disorder, or systemic pathologies are known to cause cognitive deficits.
Other
- Motor or sensory alterations that impede the rehabilitation program.
Who the study is looking for
- Over 18 years old.
- Participants with a diagnosis of COVID-19 presenting persistent neurological symptoms at least 12 weeks after acute infection.
- They will have cognitive complaints
- Consent from a physician to engage in an exercise intervention
Age in the registry: 18 years to 100 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Consorci Sanitari de Terrassa Coordinator of this site? Confirm its status | Terrassa | Spain | Unknown status |
Related publications
- Addressing persistent symptoms in post-COVID condition: Through a multimodal intervention delivered in two technology-based formats.Digit Health · 2026 · PMID 42058732
- Eye tracking and machine learning to assess cognitive impairment in post-COVID-19 patients.Sci Rep · 2026 · PMID 41851162
This page is information, not medical advice. Discuss any trial with your doctor.