NCT05847309Completed
Early vs Delayed Extubation After Endovascular Treatment for Acute Ischemic Stroke
Optimal Ventilation Time After Endovascular Treatment Under General Anesthesia for Acute Ischemic Stroke. A Prospective, Randomized Comparison Between Early vs Delayed Extubation
Source: ClinicalTrials.gov · Last updated 25 Mar 2026
Brief summary (registry, in English)
Although older studies, most of them retrospective in design, advocated sedation over general anesthesia during endovascular treatment for acute ischemic stroke, a recent meta-analysis and randomized studies have shown that general anesthesia is associated with better functional status at 3 months compared with local anesthesia and sedation. In our center, most procedures are performed under general anesthesia, and once the procedure is complete, the patient is transferred intubated and sedated to the ICU. If the patient is hemodynamically and respiratory stable, the patient will be extubated, and will be discharged to the Neurology hospitalization floor. Several factors have been described that may influence the evolution and functional status at three months of patients who have suffered a stroke and have received endovascular treatment, such as the time between the onset of symptoms and admission to the ward for performing the procedure, the use of general anesthesia compared to sedation and local anesthesia, adequate control of blood pressure, the size of the cerebral infarct, or a worse neurological examination at the time of the procedure. In turn, several factors have been described that may influence the success of extubation in a patient who has suffered an acute ischemic stroke and who has required orotracheal intubation, such as the absence of dysarthria, the size of the infarct, the location of the infarction, the NIHSS (National Institutes of health Stroke Scale) or neurological status prior to orotracheal intubation. The investigators do not know, however, whether the time of mechanical ventilation can influence the evolution and functional status at three months of patients who have suffered a stroke and have received endovascular treatment under general anesthesia
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 174 (actual)
- First submitted
- 14 Apr 2023
- Start date
- 18 Apr 2023
- Primary completion date
- 30 Jun 2025
- Lead sponsor
- Hospital Clinico Universitario de Santiago
- Diseases
- Stroke
- NCT number
- NCT05847309
What you commit to
- Study type: Interventional
- Participants enrolled: 174
- From 18 Apr 2023 to the primary completion date, 30 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who suffer bronchial aspiration prior to the endovascular procedure or during intubation.
- Patients with functional neurological status, prior to the ischemic stroke, measured with the modified Rankin scale (mRS) of value: 3-6.
Other illness
- Patients with vascular involvement of the posterior cerebral circulation, or intracranial haemorrhage associated with stroke.
Other
- Patients who have not been intubated in the interventional radiology room.
- Pregnancy
- Patients who underwent the procedure under local anesthesia and sedation.
- Patients who do not sign the informed consent by themselves or their relatives.
Who the study is looking for
- Adult (age ≥ 18 years)
- Acute ischemic stroke due to large intracranial vessel occlusion demonstrated on CT-angiography in the following anterior circulation locations (occlusion of the internal carotid artery and/or middle cerebral artery in segments M1, M2, M3) within 24 hours of symptom onset.
- Patients admitted with a NIHSS neurological status ≥ 6.
- Patients who received endovascular treatment under general anesthesia (intubated in the interventional radiology room) with satisfactory reperfusion (TICI 2b-2c-3).
- Patients admitted in the intensive care unit (ICU) with mechanical ventilation.
- Written informed consent from the patient or proxy (if present) before inclusion or once possible when patient has been included in a context of emergency.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Clinical Hospital of Santiago de Compostela Coordinator of this site? Confirm its status | Santiago de Compostela | Spain | Unknown status |
Related publications
- Early vs Delayed Extubation After Thrombectomy for Acute Ischemic Stroke: The EDESTROKE Randomized Clinical Trial.JAMA Neurol · 2026 · PMID 41910960
This page is information, not medical advice. Discuss any trial with your doctor.