Fact CheckerSign in

NCT05853913Completed

Acute Exercise on Brain Insulin Sensitivity

Impact of Acute Exercise on Brain Insulin Sensitivity in Middle-aged to Older Adults

Source: ClinicalTrials.gov · Last updated 21 Nov 2025

Brief summary (registry, in English)

Dementia is a leading cause of death in the United States among aging adults. Brain insulin resistance has emerged as a pathologic factor affecting memory, executive function as well as systemic glucose control. Regular aerobic exercise decreases Alzheimer's Disease (AD) risk, in part, through changes in brain structure and function. However, there is limited data available on how exercise impacts brain insulin resistance in aging. This study will test the effect of acute exercise on brain insulin sensitivity in middle-aged to older adults. The study will also examine cognition and cardiometabolic health in relation to brain insulin sensitivity.

Status (registry)
Completed
Study type
Interventional
Enrollment
16 (actual)
First submitted
19 Apr 2023
Start date
11 May 2023
Primary completion date
20 Mar 2025
Lead sponsor
Rutgers, The State University of New Jersey
Diseases
Obesity
NCT number
NCT05853913

What you commit to

  • Study type: Interventional
  • Participants enrolled: 16
  • From 11 May 2023 to the primary completion date, 20 Mar 2025
  • 4 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Currently taking active weight suppression medication (e.g. phentermine, orlistat, lorcaserin, naltrexone-bupropion in combination, liraglutide, benzphetamine, diethylpropion, phendimetrazine)
  • Subjects currently taking medications that affect heart rate and rhythm (i.e. Ca++ channel blockers, nitrates, alpha- or beta-blockers).

Other illness

  • Subjects with a history of significant metabolic, cardiac, congestive heart failure, cerebrovascular, hematological, pulmonary, gastrointestinal, liver, renal, or endocrine disease or cancer that in the investigator's opinion would interfere with or alter the outcome measures or impact subject safety.

Lab values

  • Subjects with abnormal estimated glomerular filtration rate (eGFR).
  • Hypertriglyceridemic (\>400 mg/dl) and hypercholesterolemic (\>260 mg/dl) subjects

Age

  • Subjects who are smokers or who have quit smoking \<1 years ago

Other

  • Subjects who have not been weight stable (\>2 kg weight change in past 3 months)
  • Hypertensive (\>160/100 mmHg)
  • Pregnant (as evidenced by positive urine pregnancy test) or nursing women
  • Subjects with contraindications to participation in an exercise
  • Current Pregnancy
  • Known contraindications for MRI imaging

Who the study is looking for

  • Male or female \>/=40 and \</=80 years old.
  • Has a body mass index \>/=25 and \</=45 kg/m2.
  • Physical Activity (\<150 min of moderate/high intensity exercise per week)

Age in the registry: 40 years to 80 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (4)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Rutgers University Loree Gymnasium
Coordinator of this site? Confirm its status		New BrunswickUnited StatesUnknown status
Institute for Food, Nutrition, and Health
Coordinator of this site? Confirm its status		New BrunswickUnited StatesUnknown status
Robert Wood Johnson University Hospital Clinical Research Center
Coordinator of this site? Confirm its status		New BrunswickUnited StatesUnknown status
Center for Advanced Human Brain Imaging Research
Coordinator of this site? Confirm its status		PiscatawayUnited StatesUnknown status

Related publications

This page is information, not medical advice. Discuss any trial with your doctor.