NCT05854160Recruiting
Stimulation-Induced Changes in Fronto-Limbic Network
Stimulation-Induced Changes in Fronto-Limbic Connectivity Control Regulation of the Emotional Response to Threat
Source: ClinicalTrials.gov · Last updated 23 Jun 2026
Brief summary (registry, in English)
The purpose of this research is to better understand how emotion processing unfolds in the brain using stereoelectroencephalography (sEEG) and direct brain stimulation. This study will use standard behavioral emotion processing tasks combined with neural recording and direct brain stimulation to assess different aspects of emotion processing. Stimulation pulses during pre and post-test periods will assess the effects of stimulation before and after conditioning, the results of which will be combined with results from the activity of each electrode during the emotion tasks to inform us of the nature of emotion processing in the brain and allow us to devise brain modulation protocols in the future.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 20 Apr 2023
- Start date
- 1 Mar 2023
- Primary completion date
- 28 Feb 2026
- Lead sponsor
- University of Alabama at Birmingham
- Diseases
- Epilepsy
- NCT number
- NCT05854160
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 1 Mar 2023 to the primary completion date, 28 Feb 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- 1\) an inability to complete the task
Who the study is looking for
- 1\) implantation of sEEG electrodes for SOC epilepsy surgery evaluation
- 2\) cognitive ability to perform simple tasks and to understand instructions
- 3\) implanted electrodes in the amygdala and medial PFC regions
- 4\) competency to understand and sign a written informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Epilepsy Monitoring Unit UAB Hospital Coordinator of this site? Confirm its status | Birmingham | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.