NCT05854524Recruiting
Exercise Neuroprotection in Parkinson's Disease
Exploring the Biological Basis for Exercise Neuroprotection in Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 3 Sept 2024 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The purpose of this study is to explore the relationships of exercise on inflammation in the body of older adults and people with Parkinson's disease (PD). This is important research for older adults but is especially important for people with PD because neuroinflammation is the main pathological mechanism that is responsible for neuron cell death in this neurodegenerative disease. As PD is a progressive disease, halting or slowing the degeneration is an important research target. Halting or slowing the disease progress is known as neuroprotection. Exercise is an attractive therapeutic treatment for people with PD as it has a lot of multi-systemic benefits, but also there is a lot of evidence to suggest that it helps improve symptoms and slow the progression of the disease. Exercise has been theorized to decrease inflammation and, therefore, has a lot of promise as a neuroprotective agent in slowing or halting the degeneration in PD. Unfortunately, there is not a lot of research that has looked into the effect of exercise on the biological processes of inflammation. Thus, the purpose of this study is to investigate the biological evidence that underlies the positive effect of exercise in people with PD.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 90 (estimated)
- First submitted
- 13 Apr 2023
- Start date
- 29 Aug 2024
- Primary completion date
- 30 May 2026
- Lead sponsor
- University of Nevada, Las Vegas
- Diseases
- Parkinson disease
- NCT number
- NCT05854524
What you commit to
- Study type: Interventional
- Planned participants: 90
- From 29 Aug 2024 to the primary completion date, 30 May 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Diagnoses, identified by self-report, that would preclude exercise participation (e.g., heart arrhythmias, uncontrolled blood pressure, exercise-induced asthma).
- Those with dementia will be excluded because there are self-report questionnaires in this study. This will be identified using the Montreal Cognitive Assessment and a score at or below a 21. Participants with mild cognitive impairment and no impairment will be included.
Age
- Those not deemed ready for exercise participation. Participants will be screened for exercise participation using the Physical Activities Readiness Questionnaire + which is used as a screening tool for all ages to identify risk factors that would clear someone for participation in moderate physical exercise.
Who the study is looking for
- 30-85 years old
- Neurologist-diagnosed PD
- Able to participate in 30 minutes of continuous moderate aerobic exercise with 2-3 short breaks per self-report.
- 30-85 years old
- No major medical diagnoses
- Able to participate in 30 minutes of continuous moderate aerobic exercise with 2-3 short breaks per self-report.
Age in the registry: 30 years to 85 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Gait and Balance Laboratory, 217 Bigelow Health Sciences Building, UNLV Coordinator of this site? Confirm its status | Las Vegas | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.