NCT05864157Recruiting
Targeted Motor Learning to Improve Gait for Individuals With Parkinson Disease
Source: ClinicalTrials.gov · Last updated 25 Jun 2026
Brief summary (registry, in English)
The purpose of this research study is to determine how training to step with a metronome on both a treadmill, as well as overground, will influence the way that people with Parkinson disease walk. Using metronomes is commonly used in clinics, but the investigators will be using a combination of slow and fast frequencies to alter the way that people walk. The use of a slower frequency metronome on the treadmill is intended to help participants take larger steps. The use of a faster frequency metronome while walking overground is intended to help participants take faster steps.This will take place over 12 training sessions. Each session will be about an hour. It will include some walking tests and pictures of the brain (using MRI) before and after training.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 45 (estimated)
- First submitted
- 8 May 2023
- Start date
- 16 Aug 2023
- Primary completion date
- 1 Jan 2027
- Lead sponsor
- University of North Carolina, Chapel Hill
- Diseases
- Parkinson disease
- NCT number
- NCT05864157
What you commit to
- Study type: Interventional
- Planned participants: 45
- From 16 Aug 2023 to the primary completion date, 1 Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- contraindications to MRI (e.g., metal implants, claustrophobia, etc)
- concurrent Physical Therapy
- have undergone deep brain stimulation surgery
Other illness
- uncontrolled cardiorespiratory/metabolic disease, or other neurological disorders or orthopedic injury that may affect gait.
Other
- cognitive deficits (Montreal Cognitive Assessment \[MoCA\] \< 26)
- cannot walk without therapist assistance
Who the study is looking for
- idiopathic Parkinson's disease (Hoehn and Yahr Stage 2-3)
- self-report the ability to walk uninterrupted for 10 minutes both overground and on a treadmill without therapist assistance
- comfortable gait speed \> 0.4 m/s and \< 1.2 m/s
- normal (or corrected to normal \[i.e., hearing aid\]) hearing
- deficits in gait continuity (e.g., shuffling, shortened strides, freezing, festination, bradykinesia, etc) based on observational gait analysis
- Movement Disorders Society - Unified Parkinson Disease Rating Scale (MDS-UPDRS-III) item 10 ≥1 and \<3
- be on stable doses of orally-administered levodopa
- age 50-80 years old
Age in the registry: 50 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of North Carolina at Chapel Hill Coordinator of this site? Confirm its status | Chapel Hill | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.