NCT05868824Active, not recruiting
Dynamic Blood Inflammatory Profile in Atopic Dermatitis Patients (ADAMUNE)
Dynamic Blood Inflammatory Profile in Atopic Dermatitis Patients
Source: ClinicalTrials.gov · Last updated 18 Mar 2026
Brief summary (registry, in English)
This is a prospective, single-center, class 2 study to better characterize the immune response in immune response in the blood of atopic dermatitis. Investigators are following in the referral center of Nice, 100 patients with atopic dermatitis. Investigators plan to include 30 patients. Blood samples will be collected to assess cytokine levels after non-specific immune stimulation. immune stimulation. Whole blood will be collected and stimulated with immune ligands (anti-CD3 T-cell stimulating ligands associated with Thymic Stromal LymphoPoietin (TSLP) or TLR agonist R848 7/8 agonist stimulating NK (natural killer) lymphocytes and promoting T cell response) on lyophilized freeze-dried spheres (LyoSphere, Qiagen) within 8 hours of blood collection.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 11 (actual)
- First submitted
- 21 Apr 2023
- Start date
- 1 Jun 2023
- Primary completion date
- 3 Feb 2026
- Lead sponsor
- Centre Hospitalier Universitaire de Nice
- Diseases
- Atopic dermatitis (eczema)
- NCT number
- NCT05868824
What you commit to
- Study type: Interventional
- Participants enrolled: 11
- From 1 Jun 2023 to the primary completion date, 3 Feb 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patient with anti-inflammatory or immunosuppressive therapy
- Patient with a contraindication to JAK inhibitors
- Participants in other clinical therapeutic studies involving a drug that may interfere with the present evaluation
Other illness
- Patient with an infection
- Patient with other systemic inflammatory disease
Other
- Vulnerable person: pregnant or nursing woman, minor, adult under guardianship or deprived of liberty
Who the study is looking for
- Patient aged ≥ 18 years.
- Patient with clinically diagnosed atopic dermatitis according to the criteria of Hanifin and Rajka.
- Moderate to severe defined by an Investigator's Global Assessment ³3 and eligible to systemic treatment.
- If the subject is a woman of childbearing potential, she has a negative urine pregnancy test.
- Subject is non-pregnant, non-lactating and is not planning for pregnancy during the study period.
- Subject is in good general health and free of any known disease state or physical condition which, in the investigator's opinion, might impair his/her evaluation or which exposes the subject to an unacceptable risk by study participation.
- Subject is able to comprehend and willing to sign an Informed Consent and/or Assent Form.
- Affiliation to a social security scheme.
- Signed informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Nice University Hospital Coordinator of this site? Confirm its status | Nice | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.