NCT05871151Completed
Combining VNS With PT Interventions for Individuals With PD
Combining Trans-auricular Vagus Nerve Stimulation With Physical Therapy Interventions for Individuals With Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 17 Dec 2025
Brief summary (registry, in English)
The purpose of this study is to evaluate the combined effects of non-invasive neuromodulation (specifically transauricular Vagus Nerve Stimulation) with exercise interventions to improve physical function and quality of life in individuals with Parkinsons Disease.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 25 (actual)
- First submitted
- 12 May 2023
- Start date
- 1 Oct 2023
- Primary completion date
- 25 May 2024
- Lead sponsor
- University of Alabama at Birmingham
- Diseases
- Parkinson disease
- NCT number
- NCT05871151
What you commit to
- Study type: Interventional
- Participants enrolled: 25
- From 1 Oct 2023 to the primary completion date, 25 May 2024
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- antidepressive or antipsychotic medication
- prior history of cardiovascular, neurological or musculoskeletal disorders known to interfere with testing PD features
Other illness
- mild cognitive impairment (MoCA \<25)
- history of seizures
- peripheral neuropathy including temporal mandibular disorders and Bells Palsy, and
Other
- self reported depression
- participation in a VNS study in the past year
- disabling bradykinesia to ensure patients are able to participate in intensive physiotherapy (based on clinical impression and in accordance to UPDRS part III item 14 - to be administered in clinic)
- implanted medical device of any type
- vasovagal syncope.
Who the study is looking for
- Diagnosis of PD by a board-certified neurologist
- age between 35 and 80 years
- no walking aids
- stable medication 4 weeks prior to and during the study
- no falls in the past 6 months
- participant must have MD who is willing to provide oversight and approval for clinically defined OFF state
Age in the registry: 35 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UAB Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
| WHARF Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.