NCT05871502Completed
Glycemia and Ischemia Reperfusion Brain Injury in Patients With Acute Cerebral Infarction Treated With Mechanical Thrombectomy
Source: ClinicalTrials.gov · Last updated 9 Sept 2026
Brief summary (registry, in English)
Postictus hyperglycemia is associated with an accelerated transformation of the ischemic penumbra into an infarct area, with increased infarct size, worse recanalization, reduced cerebral perfusion, increased ischemia reperfusion damage, and worse outcome. Furthermore, when perfusion is reinstated, hyperglycemia causes secondary tissue damage through an increase in ischemic reperfusion damage. Thus, those patients with glycemia values \< 155 mg/dL during mechanical thrombectomy, and especially at the time of reperfusion, will have greater ischemia-reperfusion damage, showing a different profile in miRNA expression, with better neurological and functional outcomes and higher risk of hemorrhagic transformation and cerebral edema. The main objective of the study is to evaluate the association between glycemia values at the time of reperfusion and stroke recovery at 3 months in patients with acute cerebral infarction treated with mechanical thrombectomy.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 107 (actual)
- First submitted
- 14 Apr 2023
- Start date
- 13 Apr 2023
- Primary completion date
- 10 Jul 2026
- Lead sponsor
- Instituto de Investigación Hospital Universitario La Paz
- Diseases
- Stroke
- NCT number
- NCT05871502
What you commit to
- Study type: Interventional
- Participants enrolled: 107
- From 13 Apr 2023 to the primary completion date, 10 Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Severe or life-threatening concomitant disease that precludes follow-up for 3 months after stroke,
- Alcohol or drug abuse
Other
- CT, angio-CT or angio-MRI showing posterior circulation occlusion.
- Participation in a therapeutic clinical trial.
Who the study is looking for
- Men and women over 18 years of age
- Neuroimaging studies such as computed tomography (CT), angio-CT or angio-MRI compatible with the diagnosis of acute cerebral infarction due to occlusion of a large vessel of the anterior circulation, including the internal carotid artery (intra- or extracranial) or middle cerebral artery (M1 or M2 segments).
- Indication of mechanical thrombectomy according to clinical practice.
- Inclusion of the patient in the study before the endovascular procedure.
- Modified Rankin Scale (mRS) score prior to stroke of 0-1.
- Signature of informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Universitario La Paz Coordinator of this site? Confirm its status | Madrid | Spain | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.