Evaluation of the Medical Benefit of Spa Therapy on Fibrosis After Radiotherapy for Breast Cancer or UADT (Upper Aerodigestive Tract) Cancer

Prior treatment

• Bilateral breast/parietal radiotherapy

Other illness

• Progressive phase of cancer
• Metastatic disease
• Patient undergoing specific treatment for breast cancer (except adjuvant hormone therapy and/or adjuvant herceptin)
• Breast prosthesis wearer for breast cancer patients
• Patient with a tracheostomy for patients with head and neck cancer
• Contraindication to spa treatment (acute inflammatory disease, active infections, heart failure with NYHA stage \> 1, chronic respiratory failure, labile hypertension, bullous disease)
• Chronic progressive dermatological disease

Other

• Obvious skin ulceration in the site of interest
• Women who are pregnant or likely to become pregnant within 6 months or who are breastfeeding
• Persons deprived of liberty or under guardianship

• Age ≥ 18 years
• In situ or invasive breast cancer or cancer of the upper aerodigestive tract
• DLQI ≥ 6 (at least moderate effect on patient's life)
• General status WHO 0-1
• Radiotherapy completed at least 6 months ago (with no maximum post radiotherapy delay)
• Unilateral breast radiotherapy for breast cancer patients
• Skin or soft tissue toxicity (- modules: Skin atrophy, fibrosis of deep connective tissues, fibrosis of superficial soft tissues) CTCAE v4.0 grade ≥ 2
• No inflammatory or infectious flare at inclusion
• Female of childbearing potential: negative urine pregnancy test at inclusion
• Patient informed and signed consent
• Affiliation to a social security systeme or equivalent