NCT05878457CompletedPhase 1
Accelerated rTMS for Post-Stroke Apathy
Accelerated rTMS for Post-Stroke Apathy: Targeting Amotivation Toward Improving Whole Health and Rehabilitation Engagement
Source: ClinicalTrials.gov · Last updated 10 Jul 2026
Brief summary (registry, in English)
This pilot study will investigate the safety, feasibility, tolerability, and preliminary efficacy of accelerated high-dose repetitive transcranial magnetic stimulation (rTMS) targeting the medial prefrontal cortex (mPFC) to address apathy symptoms in individuals with chronic stroke.
- Status (registry)
- Completed
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 21 (actual)
- First submitted
- 20 Apr 2023
- Start date
- 1 Dec 2023
- Primary completion date
- 30 Apr 2025
- Lead sponsor
- Medical University of South Carolina
- Diseases
- Stroke
- NCT number
- NCT05878457
What you commit to
- Study type: Interventional · Phase 1
- Participants enrolled: 21
- From 1 Dec 2023 to the primary completion date, 30 Apr 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concomitant neurological disorders affecting motor or cognitive function (e.g. dementia)
- Acute suicidality as assessed by the Columbia Suicide Severity Rating Scale (C-SSRS) or suicide attempt in the previous year
Other illness
- Primary extra-axial hemorrhage (subdural or subarachnoid) without ischemic stroke or intraparenchymal hemorrhage
- Visual impairment precluding completion of cognitive tasks
- Presence of contraindications to MRI or TMS including electrically, magnetically or mechanically activated metal or nonmetal implants such as cardiac pacemakers, intracerebral vascular clips, or any other electrically sensitive support system;
- History of a seizure disorder
- Active substance use disorder
- Psychotic disorders
- Bipolar 1 Disorder
Other
- Moderate or severe global aphasia
- Pregnancy (to be later confirmed by UPT in any premenopausal female participants)
- Preexisting scalp lesion, wound, bone defect, or hemicraniectomy
- Claustrophobia precluding the ability to undergo an MRI
Who the study is looking for
- 40 years old or greater
- Right- or left-hemisphere ischemic or hemorrhagic stroke with at least 6 months chronicity
- Symptomatic apathy as confirmed by (A) total score on the Apathy Evaluation Scale (AES) of ≥39 as rated by the participant or caregiver informant
- Intact cortex under the coil at the stimulation target site confirmed by neuroimaging
- Ability to participate in psychometric testing and cognitive tasks
Age in the registry: 40 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical University of South Carolina Brain Stimulation Lab Coordinator of this site? Confirm its status | Charleston | United States | Unknown status |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.