NCT05881239Recruiting
Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD
Source: ClinicalTrials.gov · Last updated 6 Mar 2026
Brief summary (registry, in English)
The goal of this study is to objectively test one's sense of smell, called olfaction, in participants with Subjective Cognitive Concerns (SCC), Mild Cognitive Impairment, Mild Behavioral Impairment (MBI), and age-matched controls. The main question it aims to answer is whether the AROMHA Brain Health Test could serve as a predictive biomarker of neurodegenerative disorders. This understanding will aid in the development of a noninvasive, cost-effective diagnostic tool that reliably and specifically distinguishes disease and normal aging populations. Participants will take the approximately 45-minute AROMHA Brain Health Smell Test where they will peel and sniff labels on the physical smell cards and answer questions on the web-based app relating to what they smelled. Participants will undergo tests for odor intensity, odor identification, odor discrimination, and episodic olfactory memory, but will not be provided the results of these tests.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 250 (estimated)
- First submitted
- 19 May 2023
- Start date
- 9 May 2023
- Primary completion date
- 30 Dec 2026
- Lead sponsor
- Massachusetts General Hospital
- Diseases
- Alzheimer disease
- NCT number
- NCT05881239
What you commit to
- Study type: Observational
- Planned participants: 250
- From 9 May 2023 to the primary completion date, 30 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current or recent (past 6 months) alcohol or substance dependence. A prior history of alcohol or substance abuse will not be grounds for exclusion.
Other illness
- Primary pulmonary disease such as severe emphysema or asthma not under good medical control.
- Current sinusitis, common cold, upper respiratory infection, or nasal polyps.
Other
- Pregnancy.
- Severe cognitive dysfunction that would preclude completion of the olfactory testing.
- An adverse reaction to fragrances (ie. they trigger a severe asthmatic attack or nausea).
Who the study is looking for
- A clinical or research consensus diagnosis of the patient's condition or control status.
- Individuals that are at least 18 years of age at the time of enrollment.
- Individuals that are no older than 100 years of age at the time of enrollment.
Age in the registry: 18 years to 100 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.