A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease

Prior treatment

• Have had acute myocardial infarction, stroke, coronary revascularization, hospitalization for unstable angina, or hospitalization due to congestive heart failure within 90 days prior to screening.
• Have taken weight loss drugs, including over-the-counter medications, within 90 days prior to screening.
• Have a prior or planned surgical treatment of obesity.
• Have a change in body weight greater than 5 kg (11 pounds) within 90 days prior to screening.

Other illness

• Have Type 1 diabetes.
• Have family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)

Other

• Have had pancreatitis.

• Have a body mass index (BMI) ≥35.0 kilogram/square meter (kg/m²).
• Have established cardiovascular (CV) disease with at least 1 of the following:
  • prior myocardial infarction
  • prior ischemic or hemorrhagic stroke, or
  • symptomatic peripheral arterial disease
• Have a history of at least 1 self-reported unsuccessful dietary effort to reduce body weight.