NCT05884723Recruiting
Preoperative Ketogenic Diet for Reduction of Hepatic Steatosis
Implementation of a Preoperative Ketogenic Diet for Reduction of Hepatic Steatosis Prior to Hepatectomy: a Randomized Control Trial
Source: ClinicalTrials.gov · Last updated 19 May 2026
Brief summary (registry, in English)
Non-alcoholic fatty liver disease is becoming increasingly common in Canada and throughout the world. Fatty liver can increase the risks of perioperative complications for those who need liver surgery. A ketogenic diet is low in carbohydrates and can be very effective in reducing liver fat content. The purpose of this randomized control trial is to compare the effect of a short duration (4 week) preoperative ketogenic diet on operative and disease outcomes in patients undergoing liver surgery. One arm will be randomized to the ketogenic diet and the other will receive standard of care pre-operative dietary consultation.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 124 (estimated)
- First submitted
- 15 May 2023
- Start date
- 1 May 2024
- Primary completion date
- Dec 2027
- Lead sponsor
- Anton Skaro
- NCT number
- NCT05884723
What you commit to
- Study type: Interventional
- Planned participants: 124
- From 1 May 2024 to the primary completion date, Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients undergoing liver resection for any other indication
Other illness
- Patients with a known bleeding disorder.
Lab values
- Patients on sodium glucose co-transporter 2 (SGLT-2) inhibitors (these are contraindicated with a ketogenic diet).
Other
- Patients without evidence of hepatic steatosis.
- Patients with evidence of liver fibrosis or cirrhosis on preoperative bloodwork or imaging.
- Patients with alcohol-related hepatic steatosis.
Who the study is looking for
- Patients 18 years of age or older undergoing any type of liver resection (e.g. wedge, formal hepatectomy), either open or laparoscopic, for colorectal liver metastases (CRLM)
- Patients with evidence of hepatic steatosis on pre-operative imaging (CT or MR) or biopsy.
- Ability to use an app based nutritional program to track macronutrient uptake throughout the dietary intervention.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| London Health Sciences Centre/Western University Coordinator of this site? Confirm its status | London | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.