NCT05889247Recruiting
Circulating Tumor DNA Guided Treatment Monitoring in Advanced Lung Cancer
Circulating Tumor DNA Guided Treatment Monitoring in Advanced Lung Cancer - a Randomized Interventional Study
Source: ClinicalTrials.gov · Last updated 9 Jan 2026
Brief summary (registry, in English)
The study is a prospective randomized interventional study including patients with advanced non-small cell lung cancer, receiving immunotherapy, with the aim of optimizing treatment monitoring. The study aims to investigate the clinical utility of liquid biopsy monitoring in order to reduce the numbers of inefficient treatments and needless toxicity - and to explore the cost-effectiveness and cost-utility of introducing liquid biopsy monitoring in daily clinical practice.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 350 (estimated)
- First submitted
- 8 May 2023
- Start date
- Jul 2023
- Primary completion date
- Jun 2027
- Lead sponsor
- Zealand University Hospital
- Diseases
- Lung cancer, Childhood cancers
- NCT number
- NCT05889247
What you commit to
- Study type: Interventional
- Planned participants: 350
- From Jul 2023 to the primary completion date, Jun 2027
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Other active cancers
Lab values
- Targetable alterations in EGFR, ALK or ROS-1
Who the study is looking for
- Newly diagnosed, histologically verified, Non-Small Cell Lung Cancer (NSCLC)
- Advanced or locally advanced disease without curative intended treatment options
- Age \> 18 years
- Eastern Cooperative Oncology Group (ECOG) score of Performance Status (PS) 0-1
- Measurable disease according to the iRECIST criteria version 1.1.
- Eligible to first line immunotherapy (monotherapy)
- Signed informed consent
Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Oncology Coordinator of this site? Confirm its status | Aalborg | Denmark | Not yet recruiting |
| Department of Clinical Oncology Coordinator of this site? Confirm its status | Hillerød | Denmark | Recruiting |
| Department of Clinical Oncology and Palliative Care Coordinator of this site? Confirm its status | Næstved | Denmark | Recruiting |
| Department of Clinical Oncology and Palliative Care Coordinator of this site? Confirm its status | Roskilde | Denmark | Recruiting |
| Department of Oncology Coordinator of this site? Confirm its status | Vejle | Denmark | Not yet recruiting |
Related publications
This page is information, not medical advice. Discuss any trial with your doctor.