NCT05889598Active, not recruiting
Resistance Exercise Training to Improve Bone and Articular Cartilage Health in Women
Effects of a Resistance Exercise Programme on Risk of Osteoporosis and Osteoarthritis in Females
Source: ClinicalTrials.gov · Last updated 21 Apr 2026
Brief summary (registry, in English)
Osteoarthritis (degenerative joint disease) and osteoporosis (weak and fragile bones) are common conditions, particularly in women after menopause, and become even more common as we get older. Aging is also associated with sarcopenia, the progressive loss of muscle strength and mass with age. In this three-arm study, the effect of resistance exercise programs with different parameters (such as velocity and load) on various outcomes, including structural changes (bone mineral density, cartilage composition, muscle size), physical function, and biomarkers will be compared.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 110 (estimated)
- First submitted
- 26 Apr 2022
- Start date
- 1 Mar 2022
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Loughborough University
- Diseases
- Osteoporosis
- NCT number
- NCT05889598
What you commit to
- Study type: Interventional
- Planned participants: 110
- From 1 Mar 2022 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Taking medication affecting bone/cartilage metabolism;
- Contraindications to MRI or DXA (e.g. Metallic implants);
Other illness
- Any existing symptomatic knee, hip, back injury or any medical conditions or injuries which would affect the ability or safety to perform exercise or influence bone/cartilage, including unstable angina, uncontrolled hypertension, a history of heart failure, and a history of cardiovascular disease and conditions;
Other
- Regular (\>once per week on average) participation in resistance training with loading greater than bodyweight or in high impact (impact greater than jogging);
- Blood pressure exceeding 150/90 mmHg;
- BMI \> 30 kg/m2;
- Osteoporotic (FRAX score according to which the participant would be advised to seek treatment);
- Fracture within the past year.
Who the study is looking for
- Women between 50-70 years;
- Experienced last menstrual cycle, hormonal contraception or menopausal hormone replacement therapy at least five years ago;
- Independent living and able to come into the university;
- Healthy women: not previously diagnosed with osteoporosis or knee osteoarthritis, other major medical conditions;
- Able to understand English.
Age in the registry: 50 years to 70 years · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Loughborough University Coordinator of this site? Confirm its status | Loughborough | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.