NCT05889845CompletedPhase 3
Candin for the Treatment of Common Warts
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of Candin for the Treatment of Common Warts (Verruca Vulgaris) in Adolescents and Adults
Source: ClinicalTrials.gov · Last updated 5 Sept 2025
Brief summary (registry, in English)
The goal of this clinical trial is to compare outcome in healthy subjects 12 years of age and older with at least 3, but no more than 20, common warts (Verruca vulgaris) following treatment with Candin or placebo. The main questions it aims to answer are: * does treatment with Candin result in better clearance of warts than placebo * how many injections are required to result in wart clearance Participants will * have one wart selected for injection every two weeks until clearance * return 12 weeks after wart clearance for assessment of durability of response
- Status (registry)
- Completed
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 330 (actual)
- First submitted
- 2 May 2023
- Start date
- 22 Jan 2025
- Primary completion date
- 27 Aug 2025
- Lead sponsor
- Nielsen BioSciences, Inc.
- NCT number
- NCT05889845
What you commit to
- Study type: Interventional · Phase 3
- Participants enrolled: 330
- From 22 Jan 2025 to the primary completion date, 27 Aug 2025
- 18 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior treatment of common warts with liquid nitrogen, carbon dioxide, electrodesiccation, laser, surgery, salicylic acid, etc., that, in the Investigator's opinion, does not exhibit complete healing from the treatment
- Treatment with immunotherapy (e.g., diphenylcyclopropenone \[DPCP\], dinitrochlorobenzene \[DNCB\], or other), imiquimod, 5-fluorouracil, bleomycin, or podophyllin within 12 weeks of the Baseline Visit or during the study
- Prior treatment with Candida albicans within 12 weeks of the Baseline Visit or during the study
- Systemic treatment with an immunosuppressive drug during the study or in the 6 months or 5 half lives prior to the Baseline Visit or during the study (e.g., azathioprine, 6 mercaptopurine, methotrexate, infliximab, adalimumab, etanercept, systemic steroids \[topical or inhaled steroids are acceptable\]).
- Use of cantharidin or an investigational agent or device within the 30 days prior to the Baseline Visit or during the study
Other illness
- Systemic or localized diseases, conditions, or medications that could interfere with the assessment of safety or efficacy or that compromise immune function
- Candin delayed type hypersensitivity reaction test wheal sized \< 5 mm or \> 25 mm at the Baseline Visit
- History of keloid formation
Who the study is looking for
- At least 3, but not more than 20 common warts (Verruca vulgaris)
- Willing to agree to use adequate contraception methods during the study
Age in the registry: 12 years to - · Sex: All · Does not accept healthy volunteers
Sites (18)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| DermResearch Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| Advocare Berlin Medical Associates Coordinator of this site? Confirm its status | Berlin | United States | Unknown status |
| Cahaba Dermatology Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
| Integrated Dermatology of Newton-Brighton Coordinator of this site? Confirm its status | Brighton | United States | Unknown status |
| Arkansas Pediatric Clinic Coordinator of this site? Confirm its status | Bryant | United States | Unknown status |
| Kaminska Dermatology Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
| Velocity Clinical Englewood Coordinator of this site? Confirm its status | Englewood | United States | Unknown status |
| Hamzavi Dermatology Coordinator of this site? Confirm its status | Fort Gratiot | United States | Unknown status |
| Johnson Dermatology Coordinator of this site? Confirm its status | Fort Smith | United States | Unknown status |
| Velocity Clinical Hampton Coordinator of this site? Confirm its status | Hampton | United States | Unknown status |
| Dermatology Clinic of Arkansas Coordinator of this site? Confirm its status | Hot Springs | United States | Unknown status |
| Velocity Clinical La Mesa Coordinator of this site? Confirm its status | La Mesa | United States | Unknown status |
| Long Beach Research Coordinator of this site? Confirm its status | Long Beach | United States | Unknown status |
| Bryn Mawr Health Center Coordinator of this site? Confirm its status | Newtown Square | United States | Unknown status |
| Schlessinger MD Coordinator of this site? Confirm its status | Omaha | United States | Unknown status |
| Austin Institute for Clinical Research Coordinator of this site? Confirm its status | Pflugerville | United States | Unknown status |
| Integrative Skin Research Coordinator of this site? Confirm its status | Sacramento | United States | Unknown status |
| Velocity Clinical Spartanburg Coordinator of this site? Confirm its status | Spartanburg | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.