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NCT05889845CompletedPhase 3

Candin for the Treatment of Common Warts

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of Candin for the Treatment of Common Warts (Verruca Vulgaris) in Adolescents and Adults

Source: ClinicalTrials.gov · Last updated 5 Sept 2025

Brief summary (registry, in English)

The goal of this clinical trial is to compare outcome in healthy subjects 12 years of age and older with at least 3, but no more than 20, common warts (Verruca vulgaris) following treatment with Candin or placebo. The main questions it aims to answer are: * does treatment with Candin result in better clearance of warts than placebo * how many injections are required to result in wart clearance Participants will * have one wart selected for injection every two weeks until clearance * return 12 weeks after wart clearance for assessment of durability of response

Status (registry)
Completed
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
330 (actual)
First submitted
2 May 2023
Start date
22 Jan 2025
Primary completion date
27 Aug 2025
Lead sponsor
Nielsen BioSciences, Inc.
NCT number
NCT05889845

What you commit to

  • Study type: Interventional · Phase 3
  • Participants enrolled: 330
  • From 22 Jan 2025 to the primary completion date, 27 Aug 2025
  • 18 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Prior treatment of common warts with liquid nitrogen, carbon dioxide, electrodesiccation, laser, surgery, salicylic acid, etc., that, in the Investigator's opinion, does not exhibit complete healing from the treatment
  • Treatment with immunotherapy (e.g., diphenylcyclopropenone \[DPCP\], dinitrochlorobenzene \[DNCB\], or other), imiquimod, 5-fluorouracil, bleomycin, or podophyllin within 12 weeks of the Baseline Visit or during the study
  • Prior treatment with Candida albicans within 12 weeks of the Baseline Visit or during the study
  • Systemic treatment with an immunosuppressive drug during the study or in the 6 months or 5 half lives prior to the Baseline Visit or during the study (e.g., azathioprine, 6 mercaptopurine, methotrexate, infliximab, adalimumab, etanercept, systemic steroids \[topical or inhaled steroids are acceptable\]).
  • Use of cantharidin or an investigational agent or device within the 30 days prior to the Baseline Visit or during the study

Other illness

  • Systemic or localized diseases, conditions, or medications that could interfere with the assessment of safety or efficacy or that compromise immune function
  • Candin delayed type hypersensitivity reaction test wheal sized \< 5 mm or \> 25 mm at the Baseline Visit
  • History of keloid formation

Who the study is looking for

  • At least 3, but not more than 20 common warts (Verruca vulgaris)
  • Willing to agree to use adequate contraception methods during the study

Age in the registry: 12 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (18)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
DermResearch
Coordinator of this site? Confirm its status
AustinUnited StatesUnknown status
Advocare Berlin Medical Associates
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BerlinUnited StatesUnknown status
Cahaba Dermatology
Coordinator of this site? Confirm its status
BirminghamUnited StatesUnknown status
Integrated Dermatology of Newton-Brighton
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BrightonUnited StatesUnknown status
Arkansas Pediatric Clinic
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BryantUnited StatesUnknown status
Kaminska Dermatology
Coordinator of this site? Confirm its status
ChicagoUnited StatesUnknown status
Velocity Clinical Englewood
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EnglewoodUnited StatesUnknown status
Hamzavi Dermatology
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Fort GratiotUnited StatesUnknown status
Johnson Dermatology
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Fort SmithUnited StatesUnknown status
Velocity Clinical Hampton
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HamptonUnited StatesUnknown status
Dermatology Clinic of Arkansas
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Hot SpringsUnited StatesUnknown status
Velocity Clinical La Mesa
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La MesaUnited StatesUnknown status
Long Beach Research
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Long BeachUnited StatesUnknown status
Bryn Mawr Health Center
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Newtown SquareUnited StatesUnknown status
Schlessinger MD
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OmahaUnited StatesUnknown status
Austin Institute for Clinical Research
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PflugervilleUnited StatesUnknown status
Integrative Skin Research
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SacramentoUnited StatesUnknown status
Velocity Clinical Spartanburg
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SpartanburgUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.