NCT05890664RecruitingPhase 3
Colchicine After Electrocardioversion for Atrial Fibrillation
Colchicine After Electrocardioversion for Atrial Fibrillation - The COLECTRO-AF Trial
Source: ClinicalTrials.gov · Last updated 28 May 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The purpose of this study is to investigate whether a 3 month treatment course of low-dose Colchicine decreases the recurrence of Atrial fibrillation (AF) after electrocardioversion (ECV) in patients with AF.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 416 (estimated)
- First submitted
- 23 May 2023
- Start date
- 14 Apr 2024
- Primary completion date
- 31 Mar 2027
- Lead sponsor
- University Hospital, Basel, Switzerland
- Diseases
- Atrial fibrillation
- NCT number
- NCT05890664
- EU CT number
- 2024-516033-12-00
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 416
- From 14 Apr 2024 to the primary completion date, 31 Mar 2027
- 12 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Pulmonary vein isolation within 3 months prior to ECV or pulmonary vein isolation planned within 3 months after ECV
- Intake of a strong inhibitor of CYP3A4 or P-Glycoprotein (clarithromycin, erythromycin, telithromycin, cyclosporine, ketoconazole or itraconazole)
Other illness
- Known intolerance or hypersensitivity to Colchicine
- Serious gastrointestinal disease (severe gastritis or diarrhea)
- Clinically overt hepatic disease
- Significant immunosuppression (e.g. due to transplantation or rheumatic disease)
Lab values
- Severe renal disease (eGFR\< 30ml/min/1.73m2)
Other
- AF persistence after cardioversion or early AF recurrence within 30 minutes after ECV
- Any other rhythm than AF before cardioversion
- Any other absolute indication for Colchicine intake
- Clinically significant blood dyscrasia (e.g., myelodysplasia)
- Pregnant or breastfeeding women, or women of child-bearing potential who do not use a highly effective form of birth control
- Life expectancy \<1 year
Who the study is looking for
- Age \>18 years
- ECG-documented AF prior to ECV
- Successful ECV with conversion of AF to sinus rhythm with persistent sinus rhythm ≥30 minutes after ECV
- Ability to give written informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (12)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospital Basel Coordinator of this site? Confirm its status | Basel | Switzerland | Recruiting |
| University Hospital Bern Coordinator of this site? Confirm its status | Bern | Switzerland | Recruiting |
| Cantonal Hospital Baselland (KSBL) Coordinator of this site? Confirm its status | Bruderholz | Switzerland | Recruiting |
| Lausanne University Hospital Coordinator of this site? Confirm its status | Lausanne | Switzerland | Recruiting |
| Lucerne Cantonal Hospital Coordinator of this site? Confirm its status | Lucerne | Switzerland | Recruiting |
| Cantonal Hospital Olten Coordinator of this site? Confirm its status | Olten | Switzerland | Recruiting |
| Herzpraxis am Rhein Coordinator of this site? Confirm its status | Rheinfelden | Switzerland | Recruiting |
| Solothurner Spitäler AG Coordinator of this site? Confirm its status | Solothurn | Switzerland | Recruiting |
| University Medical Center Freiburg, University Heart Center Coordinator of this site? Confirm its status | Bad Krozingen | Germany | Not yet recruiting |
| Herzzentrum Dresden GmbH Universitaetsklinik Coordinator of this site? Confirm its status | Dresden | Germany | Not yet recruiting |
| Marien Hospital Herne Coordinator of this site? Confirm its status | Herne | Germany | Not yet recruiting |
| Universitaetsklinikum Schleswig-Holstein AöR Coordinator of this site? Confirm its status | Luebeck | Germany | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.