NCT05892328Completed
Watermelon Dose Response Blood Pressure Study
Dose Response Effect of Watermelon Consumption on Ambulatory Blood Pressure in Adults With Pre-hypertension: A Randomized Controlled Pilot Trial
Source: ClinicalTrials.gov · Last updated 29 May 2026
Brief summary (registry, in English)
1. Primary outcome: To evaluate the dose response effects of watermelon flesh in regulating Blood Pressure (BP) in individuals with pre-hypertension. 2. Secondary outcomes: To study the dose-response effects of watermelon flesh intake on cardio-metabolic risk factors including plasma metabolic markers, lipid profile and nitrate/nitrite levels in individuals with pre-hypertension.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 39 (actual)
- First submitted
- 2 May 2023
- Start date
- 7 Apr 2023
- Primary completion date
- 1 Dec 2023
- Lead sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
- Diseases
- High blood pressure
- NCT number
- NCT05892328
What you commit to
- Study type: Interventional
- Participants enrolled: 39
- From 7 Apr 2023 to the primary completion date, 1 Dec 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Cholesterol-lowering medications, anticoagulants, blood pressure-lowering medications,) and/or taking prescription medications that may interfere with study procedures or endpoints (e.g. gastrointestinal medications, antibiotics) within the last 30 days
- Have cancer other than non-melanoma skin cancer in previous 5 years
- Addicted to drugs or alcohol
Other illness
- Have allergies/intolerances to foods consumed in the study
- Have significant psychiatric or neurological disturbances that may interfere with the ability to follow the study protocol
Lab values
- Men and women who have fasting blood glucose concentration \<100 or \>125 mg/dL at screening visit
Other
- Smoker
- Vegetarian
- Uncontrolled blood pressure ≥140 mmHg (systolic)/ ≥ 90 mmHg (diastolic)
- Over the counter supplements (e.g. fiber supplements, probiotics and/or prebiotics, antioxidants, anti-inflammation)
- Dietary supplements like (garlic, fish oil), glutamine supplements, grape seed extract, L-citrulline/arginine
- Taking unstable dose of hormonal contraceptive and/or a stable dose less than 6 months
- Planning to become pregnant, pregnant and/or breast-feeding
- Excessive exerciser or a trained athlete
- Drink excessive amount of coffee/tea (\> 5 cups per day)
- Donated blood within last 3 months
- Currently eat \> 2 servings of watermelons per day
- Actively losing weight/ trying to lose weight (unstable body weight fluctuations of \> 11 lbs in 3 months)
Who the study is looking for
- Individuals who are nonsmokers
- Healthy overweight/ obese man or woman between 25 and 65 years of age
- Blood pressure 120-160 mmHg systolic or 80-100 mm/Hg diastolic at screening visit
- Fasting blood glucose concentration between 100 mg/dL and 125 mg/dL at screening visit (value range indicate prediabetes, by finger prick and/or venous blood sampling)
- Have no clinical evidence/history of cardiovascular, metabolic, respiratory, renal, gastrointestinal, or hepatic disease
Age in the registry: 25 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Clinical Nutrition Research Center Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.