NCT05893498Active, not recruiting
Advancing Cath Lab Results With FFRangio Coronary Physiology Assessment
Source: ClinicalTrials.gov · Last updated 10 Mar 2026
Brief summary (registry, in English)
To test whether FFRangio-guided treatment is non-inferior to conventional pressure wire-guided treatment in patients with coronary artery disease.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 1924 (estimated)
- First submitted
- 25 Apr 2023
- Start date
- 21 Jun 2023
- Primary completion date
- May 2026
- Lead sponsor
- CathWorks Ltd.
- Diseases
- Coronary artery disease
- NCT number
- NCT05893498
What you commit to
- Study type: Interventional
- Planned participants: 1924
- From 21 Jun 2023 to the primary completion date, May 2026
- 59 sites in 5 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- 1\. Adult patients (≥18 years of age) with one or more study lesion(s) (diameter stenosis 50-90%) deemed appropriate for both pressure-wire and FFRangio physiologic assessment.
- General Exclusion Criteria:
- Subject with ST-elevation (MI (STEMI) within 72 hours at time of study enrollment
- Prior coronary artery bypass graft (CABG) with patent grafts to the study vessel(s)
- Patients undergoing coronary physiologic assessment where one possible outcome is referral for CABG
- The study vessel supplies a significant nonviable territory (e.g., prior transmural MI)
- Severe left sided valvular heart disease
- Most recent documented LVEF ≤30%
- Women who are pregnant or breastfeeding (women of childbearing potential are required to have negative pregnancy test within 1 week of index procedure)
- Patients with life expectancy \<1 year life as estimated by treating physician.
- Subjects enrolled in other ongoing non-registry clinical studies that would impact conduct or outcomes of this study (registries and long-term follow-up of other studies are allowed)
- Subjects who have undergone angiographic or wire-based coronary physiological assessment for 1 or more potential study lesions within 30 days of enrollment.
- Angiographic Exclusion Criteria:
- Coronary angiogram is not acquired per instructions as defined in the Study Protocol
- Sthe study lesion is the clear culprit for a NSTEACS
- Angiographic evidence of a procedural complication (e.g., acute stent thrombosis, flow-limiting dissection, perforation, slow/no reflow, or other) prior to randomization
- Thrombolysis in myocardial infarction (TIMI) Grade 2 flow or lower in any study vessel at time of enrollment
- The study vessel is in a left coronary vessel with separate left anterior descending and left circumflex ostia arising from the aorta
- The study lesion involves the left main coronary artery (stenosis ≥ 50%)
- The study lesion is in an ectatic or aneurysmal coronary segment (defined as lumen diameter 1.5x diameter or the reference vessel)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (59)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hôpitaux Universitaires Genève HUG Coordinator of this site? Confirm its status | Geneva | Switzerland | Unknown status |
| Centre Hospitalier Universitaire Vaudois (CHUV) Coordinator of this site? Confirm its status | Lausanne | Switzerland | Unknown status |
| Hôpital Cantonal de Fribourg (HFR) Coordinator of this site? Confirm its status | Villars-sur-Glâne | Switzerland | Unknown status |
| Basildon University Hospital Coordinator of this site? Confirm its status | Basildon | United Kingdom | Unknown status |
| Imperial College Healthcare Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Musgrove Park Hospital Coordinator of this site? Confirm its status | Taunton | United Kingdom | Unknown status |
| Rabin Medical Centre Coordinator of this site? Confirm its status | Petah Tikva | Israel | Unknown status |
| Golda HaSharon Hospital Coordinator of this site? Confirm its status | Petah Tikva | Israel | Unknown status |
| Fukuyama Cardiovascular Hospital Coordinator of this site? Confirm its status | Fukuyama | Japan | Unknown status |
| Gifu Heart Center Coordinator of this site? Confirm its status | Gifu | Japan | Unknown status |
| Ichinomiyanishi Hospital Coordinator of this site? Confirm its status | Ichinomiya | Japan | Unknown status |
| Kobe University Coordinator of this site? Confirm its status | Kobe | Japan | Unknown status |
| Chibanishi General Hospital Coordinator of this site? Confirm its status | Matsudo | Japan | Unknown status |
| Mie University Hospital Coordinator of this site? Confirm its status | Osaka | Japan | Unknown status |
| Sakakibara Heart Institute Coordinator of this site? Confirm its status | Tokyo | Japan | Unknown status |
| NTT Medical Center Tokyo Coordinator of this site? Confirm its status | Tokyo | Japan | Unknown status |
| Lehigh Valley Health Coordinator of this site? Confirm its status | Allentown | United States | Unknown status |
| HCA Florida JFK Hospital Coordinator of this site? Confirm its status | Atlantis | United States | Unknown status |
| MedStar Union Memorial Hospital Coordinator of this site? Confirm its status | Baltimore | United States | Unknown status |
| Beth Israel Deaconess Medical Center Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
| New York Presbyterian Methodist Hospital Coordinator of this site? Confirm its status | Brooklyn | United States | Unknown status |
| The Christ Hospital Coordinator of this site? Confirm its status | Cincinnati | United States | Unknown status |
| Mount Carmel Health System Coordinator of this site? Confirm its status | Columbus | United States | Unknown status |
| Metropolitan Heart Vascular Institute Coordinator of this site? Confirm its status | Coon Rapids | United States | Unknown status |
| Ascension St. John Hospital Coordinator of this site? Confirm its status | Detroit | United States | Unknown status |
| St. Elizabeth Healthcare Coordinator of this site? Confirm its status | Edgewood | United States | Unknown status |
| Inova Fairfax Hospital Coordinator of this site? Confirm its status | Fairfax | United States | Unknown status |
| Cardiac & Vascular Institute Coordinator of this site? Confirm its status | Gainesville | United States | Unknown status |
| University of California San Diego Health Coordinator of this site? Confirm its status | La Jolla | United States | Unknown status |
| VA- Long Beach Healthcare Coordinator of this site? Confirm its status | Long Beach | United States | Unknown status |
| UCLA Medical Center Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Keck Medicine of USC Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| University of Miami Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Minneapolis Heart Institute Foundation Coordinator of this site? Confirm its status | Minneapolis | United States | Unknown status |
| Mountainside Medical Center Coordinator of this site? Confirm its status | Montclair | United States | Unknown status |
| Morristown Medical Center Coordinator of this site? Confirm its status | Morristown | United States | Unknown status |
| New York - Presbyterian - Weill Cornell Medical Center Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Columbia University Medical Center/New York-Presbyterian Hospital Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| NYU Langone Health Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Northwell Health (Lenox Hill, North Shore, South Shore, Huntington, Staten Island)) Coordinator of this site? Confirm its status | New York | United States | Unknown status |
| Stanford University Coordinator of this site? Confirm its status | Palo Alto | United States | Unknown status |
| VA - Palo Alto Healthcare Coordinator of this site? Confirm its status | Palo Alto | United States | Unknown status |
| Hospital of the University of Pennsylvania Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Baylor Scott & White The Heart Hospital - Plano Coordinator of this site? Confirm its status | Plano | United States | Unknown status |
| The Valley Hospital Coordinator of this site? Confirm its status | Ridgewood | United States | Unknown status |
| St. Francis Hospital and Heart Center Coordinator of this site? Confirm its status | Roslyn | United States | Unknown status |
| TidalHealth, INC Coordinator of this site? Confirm its status | Salisbury | United States | Unknown status |
| HCA Methodist Healthcare of San Antonio Coordinator of this site? Confirm its status | San Antonio | United States | Unknown status |
| Kaiser Permanente-San Francisco Coordinator of this site? Confirm its status | San Francisco | United States | Unknown status |
| Ellis Hospital Coordinator of this site? Confirm its status | Schenectady | United States | Unknown status |
| St. Joesph's Medical Center Coordinator of this site? Confirm its status | Stockton | United States | Unknown status |
| HCA Florida Northside Hospital Coordinator of this site? Confirm its status | St. Petersburg | United States | Unknown status |
| Tallahassee Research Institute Coordinator of this site? Confirm its status | Tallahassee | United States | Unknown status |
| University of South Florida Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
| Archbold Hospital Coordinator of this site? Confirm its status | Thomasville | United States | Unknown status |
| Cardiac Associates Research Coordinator of this site? Confirm its status | Tupelo | United States | Unknown status |
| Carle Foundation Hospital Coordinator of this site? Confirm its status | Urbana | United States | Unknown status |
| Kansas Heart Hospital Coordinator of this site? Confirm its status | Wichita | United States | Unknown status |
| Ascension Via Christi St. Francis Coordinator of this site? Confirm its status | Wichita | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.