NCT05897632Recruiting
CARE-CP (Testing a Cardiovascular Ambulatory Rapid Evaluation for Patients With Chest Pain)
CARE-CP (Testing a Cardiovascular Ambulatory Rapid Evaluation for Patients With Chest Pain )
Source: ClinicalTrials.gov · Last updated 30 Sept 2026
Brief summary (registry, in English)
The goal of this study is to determine if rapid outpatient evaluation vs hospitalization management is the best strategy (based on patient-centered measures and safe, equitable, and efficient resource use) for evaluating patients with acute chest pain who are at moderate risk for acute coronary syndrome (ACS). Patients will be randomized in the Emergency Department to either an outpatient evaluation (CARE-CP) or hospitalization evaluation for their symptoms.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 502 (estimated)
- First submitted
- 1 Jun 2023
- Start date
- 2 Oct 2023
- Primary completion date
- Sept 2027
- Lead sponsor
- Wake Forest University Health Sciences
- Diseases
- Coronary artery disease
- NCT number
- NCT05897632
What you commit to
- Study type: Interventional
- Planned participants: 502
- From 2 Oct 2023 to the primary completion date, Sept 2027
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior Enrollment
Other illness
- ST Elevation Myocardial Infarction (STEMI) Activation
- Stress Echocardiography, Nuclear Stress Test, Stress ECG, Stress Cardiac MRI, Coronary CT Angiogram (CCTA), Invasive Coronary Angiography (Cardiac Cath) within 1 year
- "Clean" CCTA or Cardiac Cath (0% stenosis in all vessels) within the past 2 years
- Other comorbid conditions requiring hospitalization
- Unstable Vitals (Blood Pressure \<90, Heart Rate \>120 or \<50, O2 Sat \<90%)
Lab values
- End Stage Renal Disease; Dialysis or estimated glomerular filtration rate (eGFR) \<30 mL/min
Other
- ST Changes or new T-wave inversions ≥1mm on ECG
- Any Elevated Troponin Measure (Based on Sex-Specific 99th Percentile)
- Serial change between Troponin Measures (Delta) ≥5 pg/mL
- Chest Trauma
- Pregnancy
- Life Expectancy \< 1 year
- Transfers From Another Hospital
- Non-English Speaking
- Prisoners
- Already Enrolled in Other Interventional Trial
Who the study is looking for
- Age ≥21 years old
- Chest pain or Symptoms of acute coronary syndrome (ACS)
- Moderate risk of ACS (all of the below)
- Hear Score 4-6
- Non-Ischemic electrocardiogram (ECG)
- Two Troponin measures \< Sex-Specific Upper Reference Limit
- Women \<15 pg/ml
- Men \<20 pg/ml
- No prior coronary artery disease (CAD)
- No Prior Myocardial Infarction (MI)
- No Prior Coronary Revascularization Procedures
- No Patients with ≥ 70% Obstructive Coronary Disease
Age in the registry: 21 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Carolinas Medical Center Coordinator of this site? Confirm its status | Charlotte | United States | Recruiting |
| Henry Ford Hospital Coordinator of this site? Confirm its status | Detroit | United States | Recruiting |
| Wake Forest University Health Sciences Coordinator of this site? Confirm its status | Winston-Salem | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.