Home OCT-Guided Treatment Versus Treat and Extend for the Management of Neovascular AMD

Prior treatment

• Previous treatment for MNV (intravitreal injection of any anti-VEGF or anti-VEGF/anti-Ang2 agent, or any other AMD therapy)
• Prior treatment with intravitreal injection of any anti-VEGF or anti-VEGF/anti-Ang2 agent or with macular laser for any indication
• Treatment with intravitreal corticosteroids within the last 6 months

Other illness

• A condition that, in the opinion of the investigator, would preclude participation in the study or ability to complete daily Home OCT scans for 2 years (e.g., unstable medical status that may preclude successful completion of follow-up, dementia, Alzheimer's disease, uncontrollable tremors)

Other

• MNV due to other causes, such as ocular histoplasmosis, central serous choroidopathy, or pathologic myopia

• Age ≥ 50 years
• Have the capacity to consent on his/her own behalf
• Able to successfully and independently complete at least one self-scanning session on the Home OCT device located at the enrolling clinical site
• Willing to perform once daily Home OCT monitoring tests for 2 years without significant interruption (such as travel of more than 14 days)
• Best corrected E-ETDRS visual acuity ≥24 ETDRS letters (approximately 20/320 or better (Snellen))
• Previously untreated, active MNV lesion (i.e., any intraretinal or subretinal fluid within the center 3 mm diameter circle on OCT) secondary to age-related macular degeneration
• ≥ 1 intermediate drusen (≥ 63 microns) in either eye OR late AMD (MNV or macular atrophy) in the contralateral eye