NCT05905822Completed
DIetary plAnt Extracts, Colonic MicrObes, and Apoe geNetics Interactions stuDy
Source: ClinicalTrials.gov · Last updated 18 Nov 2025
Brief summary (registry, in English)
This study will involve donating a salivary sample and a faecal (stool) sample. These will be analysed in the laboratory to determine the forms of the APOE gene you are carrying (your APOE genotype) and the response of the bacteria in your colon to reactive compounds extracted from edible plants (dietary bioactives).
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 49 (actual)
- First submitted
- 6 Jun 2023
- Start date
- 19 Jun 2023
- Primary completion date
- 30 Sept 2025
- Lead sponsor
- University of East Anglia
- Diseases
- Alzheimer disease
- NCT number
- NCT05905822
What you commit to
- Study type: Observational
- Participants enrolled: 49
- From 19 Jun 2023 to the primary completion date, 30 Sept 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently a participant or have been a participant in any other study involving an investigational product within the last 4 weeks.
- Received a COVID-19 diagnosis within the last 30 days
Other illness
- Participants will be excluded from donating if they have been diagnosed with any gastrointestinal conditions such as inflammatory bowel disease.
- They will also be excluded if they have a diagnosis of any form of dementia or severe cognitive impairment.
- History or MRI evidence of brain damage, including significant trauma, stroke, learning difficulties or serious neurological disorder, including a loss of consciousness for more than 24 hours.
- Chronic fatigue syndrome, liver disease, diabetes mellitus, or gall bladder abnormalities.
- History of alcohol or drug dependency.
- Clinically diagnosed psychiatric disorder.
Other
- They currently consume a high flavonoid intake defined as \>15 portions of flavonoid rich food per day.
- Currently smoking or ceased smoking less than 6 months ago.
Who the study is looking for
- Aged between 18-35 years old or aged 55+ years old
- Fluent in written and spoken English and capacity to consent
- Availability to take part in the study
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Norwich and Norfolk University Hospital Clinical Research Facility Coordinator of this site? Confirm its status | Norwich | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.