NCT05906602Completed
Motor and Neurophysiological Changes After Ischemic Conditioning in Individuals With Stroke
Source: ClinicalTrials.gov · Last updated 19 May 2026
Brief summary (registry, in English)
The goal of this clinical trial is to test ischemic conditioning (blood flow restriction) as a neuromodulatory technique to improve gait function in stroke. Neuromodulation is emerging as a promising adjunct strategy to facilitate changes in brain activity and improve motor behavior following a neurological injury such as stroke. The main questions this trial aims to answer are: * Can ischemic conditioning produce neuromodulatory changes in the lower limb primary motor cortex? * Can ischemic conditioning be used as a neuromodulatory technique to improve strength and motor control in individuals with stroke when compared to sham ischemic conditioning? Participants will take part in two sessions of ischemic conditioning where a cuff (similar to ones that measure blood pressure) will be placed around the thigh and inflated to one of two blood flow restriction pressures (real ischemic conditioning (real IC) and sham ischemic conditioning (sham IC)). Each participant will experience measures of brain activity and motor behavior testing before and after both sessions (real IC and sham IC). Researchers will investigate ischemic conditioning as neuromodulation modality in stroke to see if ischemic conditioning can produce beneficial changes in brain activity and improvements on subsequent motor behavior tasks.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 20 (actual)
- First submitted
- 17 Feb 2023
- Start date
- 20 May 2024
- Primary completion date
- 31 Dec 2025
- Lead sponsor
- University of Illinois Chicago
- Diseases
- Stroke
- NCT number
- NCT05906602
What you commit to
- Study type: Interventional
- Participants enrolled: 20
- From 20 May 2024 to the primary completion date, 31 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous adverse reaction to TMS
- Metal implants in the head or face
Other illness
- Other neurological disorders that may interfere with motor function
- Unhealed decubiti, persistent infections that may interfere with ability to perform test procedures
- Significant cognitive or communication impairment (Mini-Mental State Examination (MMSE\<21)), which could impede the understanding of the purpose of procedures of the study
- Implanted cardiac pacemaker
- History of seizures or epilepsy
- Use of medications that could alter cortical excitability or increase risk of seizure (e.g., antidepressants, antipsychotics, anxiolytics, anticonvulsants)
- History of thrombosis (i.e., blood clots) including venous thrombosis or deep vein thrombosis (DVT).
- Blood clots in the leg, or any condition in which compression of the thigh or transient ischemia is contraindicated (i.e., open wounds in the leg, bruising, nerve damage, etc.)
- History of uncontrolled hypertension
- History of peripheral vascular disease or hematological disease
Other
- Lesions affecting the brainstem or cerebellum
- Botulinum toxin (Botox) treatments to the lower limb within the past 6 months
- Pregnant women
- Contraindications to transcranial magnetic stimulation (TMS) or ischemic conditioning (IC) (Listed below)
- TMS General Exclusion Criteria:
- Skull abnormalities or fractures
- Concussion within the last 6 months
- Unexplained, recurring headaches
- Current pregnancy
- IC General Exclusion Criteria:
- Peripheral arterial grafts in the lower extremity
Who the study is looking for
- Single, stroke \> 6 months since onset
- Residual hemiparetic gait deficits (e.g., abnormal gait pattern)
Age in the registry: 21 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Illinois Chicago Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.