NCT05907954Active, not recruitingPhase 2
(Neo)Adjuvant IDE196 (Darovasertib) in Patients With Localized Ocular Melanoma
Source: ClinicalTrials.gov · Last updated 16 Mar 2026
Brief summary (registry, in English)
Neoadjuvant/adjuvant IDE196 (darovasertib) in patients with primary uveal melanoma
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 160 (estimated)
- First submitted
- 6 Jun 2023
- Start date
- Jul 2023
- Primary completion date
- Apr 2027
- Lead sponsor
- IDEAYA Biosciences
- Diseases
- Melanoma
- NCT number
- NCT05907954
- EU CT number
- 2023-506683-14-00
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 160
- From Jul 2023 to the primary completion date, Apr 2027
- 20 sites in 7 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous treatment with a Protein Kinase C (PKC) inhibitor
- Concurrent malignant disease
- Unable to discontinue prohibited medication
Other illness
- Active HIV infection or Hep B/C
- Malabsorption disorder
- Impaired cardiac function or clinically significant cardiac disease
- Any other condition which may interfere with study interpretation or results
Who the study is looking for
- Primary localized uveal melanoma requiring either enucleation or plaque brachytherapy
- Cohort 3 (patients with small UM tumors) - clinically diagnosed uveal (not iris) melanoma that is \< 4 mm in thickness requiring treatment
- Able to dose orally
- ECOG Performance status of 0-1
- No other significant underlying ocular disease
- Adequate organ function
- Not pregnant/nursing or planning to become pregnant. Willing to use birth control
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (20)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Alfred Health Coordinator of this site? Confirm its status | Melbourne | Australia | Unknown status |
| St. Vincent's Health Sydney Coordinator of this site? Confirm its status | Sydney | Australia | Unknown status |
| Princess Margaret Cancer Centre Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Charite Universitaetsmedizin Berlin KöR Coordinator of this site? Confirm its status | Berlin | Germany | Active, not recruiting |
| Universitaetsklinikum Essen (AoR) Coordinator of this site? Confirm its status | Essen | Germany | Active, not recruiting |
| Institut Curie Coordinator of this site? Confirm its status | Paris | France | Active, not recruiting |
| Fondazione IRCCS - Istituto Nazionale dei Tumori Coordinator of this site? Confirm its status | Milan | Italy | Active, not recruiting |
| IRCCS Istituto Nazionale Tumori Fondazione Pascale Coordinator of this site? Confirm its status | Naples | Italy | Active, not recruiting |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS Coordinator of this site? Confirm its status | Rome | Italy | Active, not recruiting |
| Academisch Ziekenhuis Leiden Coordinator of this site? Confirm its status | Leiden | Netherlands | Active, not recruiting |
| University of Texas Southwestern Medical Center Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| The Cancer and Hematology Centers Coordinator of this site? Confirm its status | Grand Rapids | United States | Unknown status |
| Moores Cancer Center Coordinator of this site? Confirm its status | La Jolla | United States | Unknown status |
| Northwell Coordinator of this site? Confirm its status | Manhasset | United States | Unknown status |
| University of Miami Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Sarah Cannon Research Institute Coordinator of this site? Confirm its status | Nashville | United States | Unknown status |
| Stanford Cancer Institute Coordinator of this site? Confirm its status | Palo Alto | United States | Unknown status |
| Thomas Jefferson University Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Mayo Clinic - Rochester Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| HonorHealth Research Institute Coordinator of this site? Confirm its status | Scottsdale | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.