Impact of Microglial Activation on Synaptic Density in Alzheimer's Disease

Other illness

• Subject with a psychiatric evolutionary and/or poorly checked pathology (left to the judgement of the investigator).
• Current auto-immune disease
• Diagnosis or history of other possible etiology of dementia, including but not limited to other neurodegenerative disorders.

Age

• Known or supposed histories (≤5 years) of severe alcoholism or misuse of drugs

Other

• Subject with a grave, severe or unstable pathology (left to the judgement of the investigator) the nature of which can interfere with the variables of evaluation.
• Subject presenting contraindications to the 3T MRI
• Vascular, inflammatory or expansive, visible lesion in the MRI which can interfere on the criteria of diagnosis.
• No health insurance
• Pregnant, breast-feeding woman or planning a pregnancy in two years of follow-up.
• Person placed under the protection of justice
• Patient under guardianship or curatorship

• General Inclusion Criteria:
• Adult (older than 18 years)
• Women old enough to procreate under effective contraception
• Signed consent
• Absence of general or systemic disorders that may interfere with cognition.
• Progressive amnestic syndrome, associated or not with other cognitive impairments,
• CDR = 0.5 or 1
• Absence of general or systemic disorders that may interfere with cognition or PET imaging analysis,
• Absence of brain lesions as determined by MRI carried out within the framework of usual care.
• Presence of CSF biomarkers profile suggestive of AD
• absence of subjective problems with memory and normal scores on the MMSE (MMSE \> 27) with no more than one word missing.
• older than 50 years old.
• Scores on the Free and Cued Selective Reminding Test (FCSRT) of \>25 for free recall and \>44 for total recall.
• absence of general or systemic disorders that may interfere with cognition at follow-up.
  • Controls will be matched to AD patients for age and education level.