NCT05913232CompletedPhase 2
Study of Safety and Efficacy of H-1337 in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension
A Phase 2b Randomized, Double-masked, Active-controlled, Dose-response Study of the Safety and Efficacy of H-1337 in Subjects With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension
Source: ClinicalTrials.gov · Last updated 27 Aug 2025
Brief summary (registry, in English)
The trial will evaluate the safety and efficacy of 3 dose regimens of H-1337 \[0.6% twice daily (b.i.d.), 1.0% b.i.d. and 1.0% once in the morning (q.a.m.), and timolol maleate (0.5%, b.i.d.) in both eyes for 28 days.
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 201 (actual)
- First submitted
- 12 Jun 2023
- Start date
- 28 Aug 2023
- Primary completion date
- 29 Aug 2024
- Lead sponsor
- D. Western Therapeutics Institute, Inc.
- Diseases
- Glaucoma, High blood pressure
- NCT number
- NCT05913232
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 201
- From 28 Aug 2023 to the primary completion date, 29 Aug 2024
- 9 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Closed or very narrow angles (Grades 0-1) or those the investigator judges as occludable and/or with evidence of peripheral anterior synechiae \>/= 180 degrees by gonioscopy within 6 months prior to screening visit in either eye
- Note: Other inclusion/exclusion criteria apply.
Who the study is looking for
- Diagnosis of bilateral primary open angle glaucoma or ocular hypertension
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (9)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Dixon Eye Care Coordinator of this site? Confirm its status | Albany | United States | Unknown status |
| Skyline Vision Clinic and Laser Center Coordinator of this site? Confirm its status | Colorado Springs | United States | Unknown status |
| Global Research Management Coordinator of this site? Confirm its status | Glendale | United States | Unknown status |
| Central Florida Eye Associates Coordinator of this site? Confirm its status | Lakeland | United States | Unknown status |
| Shettle Eye Research, Inc. Coordinator of this site? Confirm its status | Largo | United States | Unknown status |
| University Eye Specialists Coordinator of this site? Confirm its status | Maryville | United States | Unknown status |
| Vistar Eye Center Coordinator of this site? Confirm its status | Roanoke | United States | Unknown status |
| Rochester Ophthalmological Group, PC Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
| Coastal Research Associates, LLC Coordinator of this site? Confirm its status | Roswell | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.