NCT05913401Completed
Exercise to Augment TMS in Those With Treatment Resistant Depression
Aerobic Exercise to Augment the Plasticity Effect of rTMS in Patients With Treatment-resistant Depression
Source: ClinicalTrials.gov · Last updated 3 Jun 2026
Brief summary (registry, in English)
Given the growing evidence that aerobic increases cortical excitability and promotes neuroplasticity, the scientific premise for its potential priming effect on the brain is strong. Combining AE with rTMS may produce a neural environment optimized for a robust physiological effect of rTMS, thereby leading to improved depression outcomes. With positive findings, this study would provide preliminary support for an innovative, safe and feasible approach for improving outcomes for this significant public health problem.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 26 (actual)
- First submitted
- 12 Jun 2023
- Start date
- 1 Feb 2024
- Primary completion date
- 30 Dec 2025
- Lead sponsor
- Butler Hospital
- Diseases
- Depression
- NCT number
- NCT05913401
What you commit to
- Study type: Interventional
- Participants enrolled: 26
- From 1 Feb 2024 to the primary completion date, 30 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Currently pregnant or plans to become pregnant in the next 6 weeks
Who the study is looking for
- adult outpatients (age 18 and above) who are already approved to receive standard TMS therapy through the Butler Hospital TMS clinic.
- able to safely engage in moderate-intensity aerobic exercise (determined by a study physician)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Butler Hospital Coordinator of this site? Confirm its status | Providence | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.