NCT05913622Recruiting
A Study on the Effects of Left Ventricular Unloading in the Setting of VA ECMO Support
Randomized Embedded Multifactorial Adaptive Platform in ExtraCorporeal Membrane Oxygenation (REMAP ECMO) - Left Ventricular Unloading Study
Source: ClinicalTrials.gov · Last updated 17 Dec 2025
Brief summary (registry, in English)
REMAP ECMO is a registry based platform in which multiple response adaptive randomized clinical trials (trial domains) will be embedded. These trial domains will, in a perpetual way, study the effects of a range of patient management strategies which aim to improve VA ECMO weaning success. A first trial domain will address the effects of left ventricular (LV) unloading through intra-aortic balloon pumping on weaning succes in VA ECMO supported patients.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 430 (estimated)
- First submitted
- 12 Jun 2023
- Start date
- 8 Jun 2023
- Primary completion date
- 1 Jul 2027
- Lead sponsor
- Erasmus Medical Center
- NCT number
- NCT05913622
What you commit to
- Study type: Interventional
- Planned participants: 430
- From 8 Jun 2023 to the primary completion date, 1 Jul 2027
- 14 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- VA ECMO usage confined to the period during surgery or another intervention (the VA ECMO was removed at the end of the intervention in the operation room).
- ECMO usage confined to the period during surgery or another intervention (the ECMO was removed at the end of the intervention).
Other illness
- Isolated right ventricular failure (e.g. due to pulmonary embolism).
Other
- Objection to participation in the registry by the patient and/or proxy
- No (deferred) informed consent provided by the patient and/or proxy.
- Pregnancy
- Left ventricular assist device (LVAD), Impella or IABP in situ.
- Ventricular septal defect or papillary muscle rupture as the cause of shock.
- Thoracic or abdominal aortic dissection.
- Moderate or severe aortic regurgitation
- Mechanical prosthesis in mitral valve position
Who the study is looking for
- Having received ECMO support for severe circulatory and/or respiratory insufficiency
- Cardiogenic shock
- Having received VA ECMO support for severe circulatory (and respiratory insufficiency).
- Age ≥ 18 years
- Initiation of LV unloading (IABP or Impella) possible ≤ 8 hours after ECMO initiation
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (14)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Az Sint Jan Brugge Coordinator of this site? Confirm its status | Bruges | Belgium | Recruiting |
| ZOL Genk Coordinator of this site? Confirm its status | Genk | Belgium | Recruiting |
| UZ Gent Coordinator of this site? Confirm its status | Ghent | Belgium | Recruiting |
| Amsterdam University Medical Center Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Not yet recruiting |
| OLVG Coordinator of this site? Confirm its status | Amsterdam | Netherlands | Recruiting |
| Amphia Hospital Coordinator of this site? Confirm its status | Breda | Netherlands | Not yet recruiting |
| Catharina hospital Coordinator of this site? Confirm its status | Eindhoven | Netherlands | Not yet recruiting |
| Leiden University Medical Center Coordinator of this site? Confirm its status | Leiden | Netherlands | Not yet recruiting |
| Maastricht UMC Coordinator of this site? Confirm its status | Maastricht | Netherlands | Recruiting |
| Antonius Hospital Coordinator of this site? Confirm its status | Nieuwegein | Netherlands | Not yet recruiting |
| Radboud UMC Coordinator of this site? Confirm its status | Nijmegen | Netherlands | Recruiting |
| Erasmus Medical Center Coordinator of this site? Confirm its status | Rotterdam | Netherlands | Recruiting |
| Haga Ziekenhuis Coordinator of this site? Confirm its status | The Hague | Netherlands | Not yet recruiting |
| University Medical Center Utrecht Coordinator of this site? Confirm its status | Utrecht | Netherlands | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.