NCT05914285Active, not recruiting
Assessment of Salbutamol Effect on Arterial Oxygenation in COPD Patients During One-lung Ventilation
Source: ClinicalTrials.gov · Last updated 1 Jul 2025
Brief summary (registry, in English)
One-lung ventilation (OLV) is essential part of anesthesia during thoracic procedures. However, OLV induces a drastic increase of intrapulmonary shunt due to maintained pulmonary perfusion through the nonventilated lung, which may result in severe hypoxemia. Although the protective mechanisms of hypoxic pulmonary vasoconstriction favorably modulate pulmonary perfusion to the ventilated lung, the effect is attenuated in patients with history of chronic obstructive pulmonary disease (COPD), which alters compliance of the pulmonary artery. Salbutamol is a selective short-acting beta2-agonist and when inhaled during OLV, it acts selectively on the pulmonary vasculature reducing pulmonary vascular resistance of well-ventilated lung. We hypothesized that inhaled salbutamol would alleviate ventilation-perfusion mismatch during OLV of COPD patients, and aimed to assess the effects of salbutamol on oxygenation in these patients.
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 90 (actual)
- First submitted
- 13 Jun 2023
- Start date
- 25 Apr 2023
- Primary completion date
- 20 Jun 2025
- Lead sponsor
- Yonsei University
- Diseases
- COPD
- NCT number
- NCT05914285
What you commit to
- Study type: Interventional
- Participants enrolled: 90
- From 25 Apr 2023 to the primary completion date, 20 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- New York Heart Association class \>II
- History of severe coronary artery occlusive disease, unstable angina, or recent myocardial infarction within 6 months
- History of pulmonary hypertension or pulmonary edema
- History of cerebrovascular accident within 3 months
Lab values
- AST level ≥100 IU/mL or ALT ≥ level 50 IU/L
- Creatinine clearance \< 30mL/min
Who the study is looking for
- Patient age 40\~80yrs, scheduled for videoscope-assisted pulmonary lobectomy
- American Society of Anesthesiologists Class III 또는 IV
- Moderate or more severe COPD according to GOLD criteria (FEV1/FVC\<70%, FEV1\<80%)
Age in the registry: 40 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Severance Hospital, Yonsei University Health System Coordinator of this site? Confirm its status | Seoul | South Korea | Unknown status |
Related publications
- Effect of salbutamol during one-lung ventilation in patients with chronic obstructive pulmonary disease: a randomized controlled trial.Can J Anaesth · 2026 · PMID 42645752
This page is information, not medical advice. Discuss any trial with your doctor.