NCT05914649Recruiting
NC Testing in LC & POTS
Neurocognitive Testing in Long COVID and Postural Tachycardia Syndrome Patients With Normal Saline: A Pilot Study
Source: ClinicalTrials.gov · Last updated 7 May 2026
Brief summary (registry, in English)
Patients with Postural Orthostatic Tachycardia Syndrome (POTS) and Post-Acute Sequelae of COVID (PASC, or "Long COVID") experience cognitive dysfunction. The investigators will test the hypothesis that 999 mL of IV saline will improve cognitive function in patients with POTS and Long COVID compared to placebo (50 mL of saline).
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 13 Jun 2023
- Start date
- 19 Sept 2024
- Primary completion date
- 31 Dec 2030
- Lead sponsor
- University of Calgary
- Diseases
- Long COVID and ME/CFS
- NCT number
- NCT05914649
What you commit to
- Study type: Interventional
- Planned participants: 100
- From 19 Sept 2024 to the primary completion date, 31 Dec 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Other factors which are in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies or an unpredictable schedule.
Other
- Patients with overt causes for POTS (e.g., dehydration, prolonged bed rest)
- An inability to safely withdraw from medicine(s) that could make test interpretation difficult and impossible.
- Unable to give an informed consent.
Who the study is looking for
- Patients with diagnosis of Long COVID
- SARS-COV2 test positive
- Symptoms \> 12 weeks post COVID
- Subjective complaint of 'brain fog" or cognitive dysfunction
- Patients with diagnosis of Postural Orthostatic Syndrome (POTS) from the Calgary Autonomic Investigation and Management Clinic
- Subjective complaint of 'brain fog" or cognitive impairment
- Healthy participants
- Without POTS or "brain fog"
- Age 18 to 60 years
- Female and Male
- Able to give an informed consent
Age in the registry: 18 years to 60 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Of Calgary Coordinator of this site? Confirm its status | Calgary | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.