NCT05918575Recruiting
Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients
A Randomized Controlled Trial of Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients
Source: ClinicalTrials.gov · Last updated 7 Aug 2026
Brief summary (registry, in English)
Around 20% of the obese patients with higher body mass index (BMI) who are taken off the breathing tube and breathing machine (ventilator) end up needing it back to support breathing. The re-application of breathing tube is associated with poor outcomes, including high risk of pneumonia, longer hospital stays, and death. The purpose of this study is to assess if prophylactic use of noninvasive breathing support after removing the breathing tube lowers the chance of needing the breathing tube again.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 250 (estimated)
- First submitted
- 15 Jun 2023
- Start date
- 10 Jul 2023
- Primary completion date
- 1 Jul 2028
- Lead sponsor
- Rush University Medical Center
- Diseases
- Obesity
- NCT number
- NCT05918575
What you commit to
- Study type: Interventional
- Planned participants: 250
- From 10 Jul 2023 to the primary completion date, 1 Jul 2028
- 5 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Underlying neuromuscular disease
- Documented/known history of chronic hypercapnic respiratory failure on home NIV (including bilevel PAP).
Other
- Pregnant
- Use of extra-corporeal membrane oxygenation
- Chronic tracheostomy in place
- Unplanned or accidental extubation
- Terminal/compassionate extubation
- Contraindication to NIV use
- Intubated because of an acute exacerbation of COPD
- No reintubation requested by patient/family
- Enrolled in any other outcome study
- Treating clinician feels that HFNC or NIV are either mandatory or contraindicated for a given patient
Who the study is looking for
- Adult, age ≥ 18 years old
- Receiving invasive mechanical ventilation for ≥24 hours
- BMI ≥40 kg/m2
- Undergoing planned extubation per treating team
- Arterial pH ≥7.35 or venous pH ≥ 7.31 within 30 mins of spontaneous breathing trial (SBT)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Civil Fray Antonio Alcalde Coordinator of this site? Confirm its status | Guadalajara | Mexico | Recruiting |
| Rush University Medical Center Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| McGovern Medical School, The University of Texas Health Science Center Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
| Medical College of Wisconsin Coordinator of this site? Confirm its status | Milwaukee | United States | Recruiting |
| Central DuPage Hospital Coordinator of this site? Confirm its status | Winfield | United States | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.