NCT05919043Completed
Upper Limb-based Movement Priming for Lower Limb Neuroplasticity & Motor Recovery in Stroke
Source: ClinicalTrials.gov · Last updated 2 Jul 2025
Brief summary (registry, in English)
The goal of this clinical trial is to to determine the effect of movement-based priming using the upper limbs on lower limb neuroplasticity and behaviors in chronic stroke. The main questions we aim to answer are: 1. What are the acute effect of UL-priming on lower limb neuroplasticity and motor behaviors in persons with stroke compared to other priming modalities? 2. What are the time effects of UL-priming on neuroplasticity and motor behavior in individuals with stroke? In this cross over study, participants will be involved in three priming sessions involving \- UL-priming using rhythmic, symmetric, bilateral priming involving the movement of at least one major joint in the upper limbs. AND \- Sham priming using auditory stimulation (1 Hz metronome). AND \- Lower-limb movement-based priming using rhythmic, symmetric, dorsiflexion and plantarflexion movements. Researchers will compare outcome measures between the different priming sessions.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 17 (actual)
- First submitted
- 1 May 2023
- Start date
- 1 Jul 2024
- Primary completion date
- 25 Jun 2025
- Lead sponsor
- University of Illinois Chicago
- Diseases
- Stroke
- NCT number
- NCT05919043
What you commit to
- Study type: Interventional
- Participants enrolled: 17
- From 1 Jul 2024 to the primary completion date, 25 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Use of anti-spasticity medications
- Previous adverse reaction to TMS
- Concussion within the prior 6 months
- Metal implants in the head or face
Other illness
- Existence of other neurological disorders
- Uncontrolled medical conditions (such as uncontrolled hypertension, untreated cardiac disease, or untreated pulmonary disease)
- Implanted cardiac pacemaker
- History of seizures or epilepsy
- Use of medications that could alter cortical excitability or increase risk of seizure (e.g., antidepressants, antipsychotics, anxiolytics, anticonvulsants)
Other
- Have brainstem or cerebellar lesions.
- Score of ≥2 on the Modified Ashworth Scale.
- MMSE score of \<21, to ensure they will follow instructions.
- Non-English-speaking individuals
- Bone, joint or soft tissue injury
- No Motor evoked potentials (MEPs) during TMS
- TMS exclusion criteria
- Skull abnormalities or fractures
- Unexplained, recurring headaches
- Current pregnancy
Who the study is looking for
- Single, monohemispheric stroke
- Chronic stroke (\> 6 months prior)
- Residual hemiparetic gait deficits (e.g., abnormal gait pattern)
- Minimum score of stage 2 on the Chedoke Arm Impairment Scale which includes stage 2, task 3 (facilitated elbow flexion) as one of the stage 2 tasks.
Age in the registry: 40 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Brain Plasticity Lab Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.